Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature

[Image: see text] PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin–proteasome system to degrade a protein of interest for therapeutic benefit. Advances made in targeted protein degradation technology have been remarkable, with several molecules having moved into clinical studies. However,...

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Detalles Bibliográficos
Autores principales: Trapotsi, Maria-Anna, Mouchet, Elizabeth, Williams, Guy, Monteverde, Tiziana, Juhani, Karolina, Turkki, Riku, Miljković, Filip, Martinsson, Anton, Mervin, Lewis, Pryde, Kenneth R., Müllers, Erik, Barrett, Ian, Engkvist, Ola, Bender, Andreas, Moreau, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295119/
https://www.ncbi.nlm.nih.gov/pubmed/35793809
http://dx.doi.org/10.1021/acschembio.2c00076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295119/
https://www.ncbi.nlm.nih.gov/pubmed/35793809
http://dx.doi.org/10.1021/acschembio.2c00076

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