Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth

[Image: see text] Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic acid derivatives able to inhibit t...

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Detalles Bibliográficos
Autores principales: Bozzola, Tiago, Scalise, Mariafrancesca, Larsson, Christer U., Newton-Vesty, Michael C., Rovegno, Caterina, Mitra, Ankita, Cramer, Jonathan, Wahlgren, Weixiao Yuan, Radhakrishnan Santhakumari, Partha, Johnsson, Richard E., Schwardt, Oliver, Ernst, Beat, Friemann, Rosmarie, Dobson, Renwick C. J., Indiveri, Cesare, Schelin, Jenny, Nilsson, Ulf J., Ellervik, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295122/
https://www.ncbi.nlm.nih.gov/pubmed/35675124
http://dx.doi.org/10.1021/acschembio.2c00321

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