Optochemical Control of TET Dioxygenases Enables Kinetic Insights into the Domain-Dependent Interplay of TET1 and MBD1 while Oxidizing and Reading 5-Methylcytosine

[Image: see text] Methyl-CpG binding domain (MBD) proteins and ten-eleven-translocation (TET) dioxygenases are the readers and erasers of 5-methylcytosine (5mC), the central epigenetic mark of mammalian DNA. We employ light-activatable human TET1 controlled by a genetically encoded photocaged serine...

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Detalles Bibliográficos
Autores principales: Lin, Tzu-Chen, Palei, Shubhendu, Summerer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295125/
https://www.ncbi.nlm.nih.gov/pubmed/35709470
http://dx.doi.org/10.1021/acschembio.2c00245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295125/
https://www.ncbi.nlm.nih.gov/pubmed/35709470
http://dx.doi.org/10.1021/acschembio.2c00245

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