Cargando…

Optochemical Control of TET Dioxygenases Enables Kinetic Insights into the Domain-Dependent Interplay of TET1 and MBD1 while Oxidizing and Reading 5-Methylcytosine

[Image: see text] Methyl-CpG binding domain (MBD) proteins and ten-eleven-translocation (TET) dioxygenases are the readers and erasers of 5-methylcytosine (5mC), the central epigenetic mark of mammalian DNA. We employ light-activatable human TET1 controlled by a genetically encoded photocaged serine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Tzu-Chen, Palei, Shubhendu, Summerer, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295125/ https://www.ncbi.nlm.nih.gov/pubmed/35709470 http://dx.doi.org/10.1021/acschembio.2c00245

Ejemplares similares

Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns
por: Adam, Sabrina, et al.
Publicado: (2022)

Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA
por: Hashimoto, Hideharu, et al.
Publicado: (2013)

Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE(−/−) mice
por: Peng, Juan, et al.
Publicado: (2016)

Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity
por: Wang, Jing, et al.
Publicado: (2017)

Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by Escherichia coli
por: Qin, Wanhai, et al.
Publicado: (2021)

TET Methylcytosine Oxidases in T Cell and B Cell Development and Function
por: Tsagaratou, Ageliki, et al.
Publicado: (2017)

Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA
por: Hashimoto, Hideharu, et al.
Publicado: (2015)

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
por: Ko, Myunggon, et al.
Publicado: (2010)

TET-mediated 5-methylcytosine oxidation in tRNA promotes translation
por: Shen, Hui, et al.
Publicado: (2020)

Effects of hypoxia on DNA hydroxymethylase Tet methylcytosine dioxygenase 2 in a KG-1 human acute myeloid leukemia cell line and its mechanism
por: He, Ping, et al.
Publicado: (2021)

Evolved DNA Duplex Readers for Strand-Asymmetrically Modified 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads
por: Buchmuller, Benjamin C., et al.
Publicado: (2022)

Decoding the role of TET family dioxygenases in lineage specification
por: Wu, Xinwei, et al.
Publicado: (2018)

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise
por: Ludwig, Anne K., et al.
Publicado: (2017)

Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation
por: Arroyo, María, et al.
Publicado: (2022)

Positive/negative ion-switching-based LC–MS/MS method for quantification of cytosine derivatives produced by the TET-family 5-methylcytosine dioxygenases
por: Dey, Aninda Sundar, et al.
Publicado: (2020)

TET‐Like Oxidation in 5‐Methylcytosine and Derivatives: A Computational and Experimental Study
por: Jonasson, Niko S. W., et al.
Publicado: (2021)

TET family dioxygenases and DNA demethylation in stem cells and cancers
por: An, Jungeun, et al.
Publicado: (2017)

Whole‐genome analysis of TET dioxygenase function in regulatory T cells
por: Yue, Xiaojing, et al.
Publicado: (2021)

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis
por: Joshi, Kanak, et al.
Publicado: (2022)

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker
por: Pantier, Raphaël, et al.
Publicado: (2019)

Nanog, Oct4 and Tet1 interplay in establishing pluripotency
por: Olariu, Victor, et al.
Publicado: (2016)

Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation
por: Clark, Tyson A, et al.
Publicado: (2013)

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
por: Müller, Udo, et al.
Publicado: (2014)

Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA
por: Liu, Shuo, et al.
Publicado: (2013)

Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism
por: Crawford, Daniel J., et al.
Publicado: (2016)

Effects of Tet-Induced Oxidation Products of 5-Methylcytosine on DNA Replication in Mammalian Cells
por: Ji, Debin, et al.
Publicado: (2014)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

A TET Homologue Protein from Coprinopsis cinerea (CcTET) That Biochemically Converts 5-Methylcytosine to 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine
por: Zhang, Liang, et al.
Publicado: (2014)

Insights into DNA hydroxymethylation in the honeybee from in-depth analyses of TET dioxygenase
por: Wojciechowski, Marek, et al.
Publicado: (2014)

Reduced mRNA and Protein Expression Levels of Tet Methylcytosine Dioxygenase 3 in Endothelial Progenitor Cells of Patients of Type 2 Diabetes With Peripheral Artery Disease
por: Zhao, Shi, et al.
Publicado: (2018)

The upregulation of NLRP3 inflammasome in dorsal root ganglion by ten-eleven translocation methylcytosine dioxygenase 2 (TET2) contributed to diabetic neuropathic pain in mice
por: Chen, Wen, et al.
Publicado: (2022)

Author Correction: Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation
por: Arroyo, María, et al.
Publicado: (2023)

Nanog-dependent function of Tet1 and Tet2 in establishment of pluripotency
por: Costa, Yael, et al.
Publicado: (2013)

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells
por: Putiri, Emily L, et al.
Publicado: (2014)

Effects of Tet-mediated Oxidation Products of 5-Methylcytosine on DNA Transcription in vitro and in Mammalian Cells
por: You, Changjun, et al.
Publicado: (2014)

Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules
por: Liu, Nan, et al.
Publicado: (2013)

TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes
por: Gurnari, Carmelo, et al.
Publicado: (2022)

Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation
por: van der Veer, Bernard K, et al.
Publicado: (2023)

The “epiTet” of Air Pollution: Epigenetic Regulation of Airway Inflammation by Tet1
por: Ji, Hong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6vblul2dhrfcjjfp43m2d2r0rq