Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis

[Image: see text] A visible-light photocatalytic radical addition reaction of dihydroquinoxalin-2-ones to trifluoromethyl ketones has been established using Ru(bpy)(3)Cl(2) as photocatalyst, acetonitrile as solvent, and HP Single Blue LED as the source of light. The reaction provides a straightforwa...

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Autores principales: Rostoll-Berenguer, Jaume, Martín-López, María, Blay, Gonzalo, Pedro, José R., Vila, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295130/
https://www.ncbi.nlm.nih.gov/pubmed/35790099
http://dx.doi.org/10.1021/acs.joc.2c01139
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author Rostoll-Berenguer, Jaume
Martín-López, María
Blay, Gonzalo
Pedro, José R.
Vila, Carlos
author_facet Rostoll-Berenguer, Jaume
Martín-López, María
Blay, Gonzalo
Pedro, José R.
Vila, Carlos
author_sort Rostoll-Berenguer, Jaume
collection PubMed
description [Image: see text] A visible-light photocatalytic radical addition reaction of dihydroquinoxalin-2-ones to trifluoromethyl ketones has been established using Ru(bpy)(3)Cl(2) as photocatalyst, acetonitrile as solvent, and HP Single Blue LED as the source of light. The reaction provides a straightforward approach to the synthesis of dihydroquinoxalin-2-ones bearing a trifluoromethyl-substituted tertiary alcohol moiety in moderate to good yields under mild conditions.
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spelling pubmed-92951302022-07-20 Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis Rostoll-Berenguer, Jaume Martín-López, María Blay, Gonzalo Pedro, José R. Vila, Carlos J Org Chem [Image: see text] A visible-light photocatalytic radical addition reaction of dihydroquinoxalin-2-ones to trifluoromethyl ketones has been established using Ru(bpy)(3)Cl(2) as photocatalyst, acetonitrile as solvent, and HP Single Blue LED as the source of light. The reaction provides a straightforward approach to the synthesis of dihydroquinoxalin-2-ones bearing a trifluoromethyl-substituted tertiary alcohol moiety in moderate to good yields under mild conditions. American Chemical Society 2022-07-05 2022-07-15 /pmc/articles/PMC9295130/ /pubmed/35790099 http://dx.doi.org/10.1021/acs.joc.2c01139 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Rostoll-Berenguer, Jaume
Martín-López, María
Blay, Gonzalo
Pedro, José R.
Vila, Carlos
Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis
title Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis
title_full Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis
title_fullStr Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis
title_full_unstemmed Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis
title_short Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis
title_sort radical addition of dihydroquinoxalin-2-ones to trifluoromethyl ketones under visible-light photoredox catalysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295130/
https://www.ncbi.nlm.nih.gov/pubmed/35790099
http://dx.doi.org/10.1021/acs.joc.2c01139
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