RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development

BACKGROUND: Secreted R-spondin (RSPO) proteins play a key role in reproductive organ development, epithelial stem cell renewal and cancer induction by reinforcing canonical Wnt signaling. We have previously reported that palmoplantar keratoderma (PPK), predisposition to cutaneous squamous cell carci...

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Detalles Bibliográficos
Autores principales: Dellambra, Elena, Cordisco, Sonia, Delle Monache, Francesca, Bondanza, Sergio, Teson, Massimo, Nicodemi, Ezio Maria, Didona, Biagio, Condorelli, Angelo Giuseppe, Camerino, Giovanna, Castiglia, Daniele, Guerra, Liliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295301/
https://www.ncbi.nlm.nih.gov/pubmed/35854363
http://dx.doi.org/10.1186/s13023-022-02434-2

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