Cargando…

Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}

BACKGROUND: Advances in hematopoietic cell transplantation (HCT) have led to marked improvements in survival. However, adolescents and young adults (AYAs) who undergo HCT are at high risk of developing sarcopenia (loss of skeletal muscle mass) due to the impact of HCT-related exposures on the develo...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Minkeun, Armenian, Saro H., Bhandari, Rusha, Lee, Kyuwan, Ness, Kirsten, Putt, Mary, Lindenfeld, Lanie, Manoukian, Saro, Wade, Kristin, Dedio, Anna, Guzman, Tati, Hampton, Isabella, Lin, Kimberly, Baur, Joseph, McCormack, Shana, Mostoufi-Moab, Sogol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295440/
https://www.ncbi.nlm.nih.gov/pubmed/35854224
http://dx.doi.org/10.1186/s12885-022-09845-1
_version_ 1784750057870852096
author Song, Minkeun
Armenian, Saro H.
Bhandari, Rusha
Lee, Kyuwan
Ness, Kirsten
Putt, Mary
Lindenfeld, Lanie
Manoukian, Saro
Wade, Kristin
Dedio, Anna
Guzman, Tati
Hampton, Isabella
Lin, Kimberly
Baur, Joseph
McCormack, Shana
Mostoufi-Moab, Sogol
author_facet Song, Minkeun
Armenian, Saro H.
Bhandari, Rusha
Lee, Kyuwan
Ness, Kirsten
Putt, Mary
Lindenfeld, Lanie
Manoukian, Saro
Wade, Kristin
Dedio, Anna
Guzman, Tati
Hampton, Isabella
Lin, Kimberly
Baur, Joseph
McCormack, Shana
Mostoufi-Moab, Sogol
author_sort Song, Minkeun
collection PubMed
description BACKGROUND: Advances in hematopoietic cell transplantation (HCT) have led to marked improvements in survival. However, adolescents and young adults (AYAs) who undergo HCT are at high risk of developing sarcopenia (loss of skeletal muscle mass) due to the impact of HCT-related exposures on the developing musculoskeletal system. HCT survivors who have sarcopenia also have excess lifetime risk of non-relapse mortality. Therefore, interventions that increase skeletal muscle mass, metabolism, strength, and function are needed to improve health in AYA HCT survivors. Skeletal muscle is highly reliant on mitochondrial energy production, as reflected by oxidative phosphorylation (OXPHOS) capacity. Exercise is one approach to target skeletal muscle mitochondrial OXPHOS, and in turn improve muscle function and strength. Another approach is to use “exercise enhancers”, such as nicotinamide riboside (NR), a safe and well-tolerated precursor of nicotinamide adenine dinucleotide (NAD(+)), a cofactor that in turn impacts muscle energy production. Interventions combining exercise with exercise enhancers like NR hold promise, but have not yet been rigorously tested in AYA HCT survivors. METHODS/DESIGN: We will perform a randomized controlled trial testing 16 weeks of in-home aerobic and resistance exercise and NR in AYA HCT survivors, with a primary outcome of muscle strength via dynamometry and a key secondary outcome of cardiovascular fitness via cardiopulmonary exercise testing. We will also test the effects of these interventions on i) muscle mass via dual energy x-ray absorptiometry; ii) muscle mitochondrial OXPHOS via an innovative non-invasive MRI-based technique, and iii) circulating correlates of NAD(+) metabolism via metabolomics. Eighty AYAs (ages 15-30y) will be recruited 6–24 months post-HCT and randomized to 1 of 4 arms: exercise + NR, exercise alone, NR alone, or control. Outcomes will be collected at baseline and after the 16-week intervention. DISCUSSION: We expect that exercise with NR will produce larger changes than exercise alone in key outcomes, and that changes will be mediated by increases in muscle OXPHOS. We will apply the insights gained from this trial to develop individualized, evidence-supported precision initiatives that will reduce chronic disease burden in high-risk cancer survivors. TRIAL REGISTRATION: ClinicalTrials.gov, NCT05194397. Registered January 18, 2022, https://clinicaltrials.gov/ct2/show/NCT05194397 {2a}. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09845-1.
format Online
Article
Text
id pubmed-9295440
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-92954402022-07-20 Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1} Song, Minkeun Armenian, Saro H. Bhandari, Rusha Lee, Kyuwan Ness, Kirsten Putt, Mary Lindenfeld, Lanie Manoukian, Saro Wade, Kristin Dedio, Anna Guzman, Tati Hampton, Isabella Lin, Kimberly Baur, Joseph McCormack, Shana Mostoufi-Moab, Sogol BMC Cancer Study Protocol BACKGROUND: Advances in hematopoietic cell transplantation (HCT) have led to marked improvements in survival. However, adolescents and young adults (AYAs) who undergo HCT are at high risk of developing sarcopenia (loss of skeletal muscle mass) due to the impact of HCT-related exposures on the developing musculoskeletal system. HCT survivors who have sarcopenia also have excess lifetime risk of non-relapse mortality. Therefore, interventions that increase skeletal muscle mass, metabolism, strength, and function are needed to improve health in AYA HCT survivors. Skeletal muscle is highly reliant on mitochondrial energy production, as reflected by oxidative phosphorylation (OXPHOS) capacity. Exercise is one approach to target skeletal muscle mitochondrial OXPHOS, and in turn improve muscle function and strength. Another approach is to use “exercise enhancers”, such as nicotinamide riboside (NR), a safe and well-tolerated precursor of nicotinamide adenine dinucleotide (NAD(+)), a cofactor that in turn impacts muscle energy production. Interventions combining exercise with exercise enhancers like NR hold promise, but have not yet been rigorously tested in AYA HCT survivors. METHODS/DESIGN: We will perform a randomized controlled trial testing 16 weeks of in-home aerobic and resistance exercise and NR in AYA HCT survivors, with a primary outcome of muscle strength via dynamometry and a key secondary outcome of cardiovascular fitness via cardiopulmonary exercise testing. We will also test the effects of these interventions on i) muscle mass via dual energy x-ray absorptiometry; ii) muscle mitochondrial OXPHOS via an innovative non-invasive MRI-based technique, and iii) circulating correlates of NAD(+) metabolism via metabolomics. Eighty AYAs (ages 15-30y) will be recruited 6–24 months post-HCT and randomized to 1 of 4 arms: exercise + NR, exercise alone, NR alone, or control. Outcomes will be collected at baseline and after the 16-week intervention. DISCUSSION: We expect that exercise with NR will produce larger changes than exercise alone in key outcomes, and that changes will be mediated by increases in muscle OXPHOS. We will apply the insights gained from this trial to develop individualized, evidence-supported precision initiatives that will reduce chronic disease burden in high-risk cancer survivors. TRIAL REGISTRATION: ClinicalTrials.gov, NCT05194397. Registered January 18, 2022, https://clinicaltrials.gov/ct2/show/NCT05194397 {2a}. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09845-1. BioMed Central 2022-07-19 /pmc/articles/PMC9295440/ /pubmed/35854224 http://dx.doi.org/10.1186/s12885-022-09845-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Study Protocol
Song, Minkeun
Armenian, Saro H.
Bhandari, Rusha
Lee, Kyuwan
Ness, Kirsten
Putt, Mary
Lindenfeld, Lanie
Manoukian, Saro
Wade, Kristin
Dedio, Anna
Guzman, Tati
Hampton, Isabella
Lin, Kimberly
Baur, Joseph
McCormack, Shana
Mostoufi-Moab, Sogol
Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}
title Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}
title_full Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}
title_fullStr Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}
title_full_unstemmed Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}
title_short Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}
title_sort exercise training and nr supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295440/
https://www.ncbi.nlm.nih.gov/pubmed/35854224
http://dx.doi.org/10.1186/s12885-022-09845-1
work_keys_str_mv AT songminkeun exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT armeniansaroh exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT bhandarirusha exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT leekyuwan exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT nesskirsten exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT puttmary exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT lindenfeldlanie exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT manoukiansaro exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT wadekristin exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT dedioanna exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT guzmantati exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT hamptonisabella exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT linkimberly exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT baurjoseph exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT mccormackshana exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1
AT mostoufimoabsogol exercisetrainingandnrsupplementationtoimprovemusclemassandfitnessinadolescentandyoungadulthematopoieticcelltransplantsurvivorsarandomizedcontrolledtrial1