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Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer
BACKGROUND: We studied the magnetic resonance spectroscopy (MRS) associations with clinicopathologic features of estrogen-dependent endometrial cancer (type I EC). METHODS: Totally 45 patients with type I EC who underwent preoperative multi-voxel MRS at 3.0 T were enrolled. The mean ratio of the Cho...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295509/ https://www.ncbi.nlm.nih.gov/pubmed/35850646 http://dx.doi.org/10.1186/s12880-022-00856-9 |
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author | Zhang, Jie Liu, Qingwei Li, Jie Liu, Zhiling Wang, Ximing Li, Na Huang, Zhaoqin Xu, Han |
author_facet | Zhang, Jie Liu, Qingwei Li, Jie Liu, Zhiling Wang, Ximing Li, Na Huang, Zhaoqin Xu, Han |
author_sort | Zhang, Jie |
collection | PubMed |
description | BACKGROUND: We studied the magnetic resonance spectroscopy (MRS) associations with clinicopathologic features of estrogen-dependent endometrial cancer (type I EC). METHODS: Totally 45 patients with type I EC who underwent preoperative multi-voxel MRS at 3.0 T were enrolled. The mean ratio of the Cho peak integral to the unsuppressed water peak integral (Cho/water) of the tumor was calculated. The Cho/water and apparent diffusion coefficient (ADC) of type I EC with and without local invasion, as well as with different levels of Ki-67 staining index (SI) (≤ 40% and > 40%), were compared. Correlation test was used to examine the relationship of Cho/water, as well as mean ADC, with Ki-67 SI, tumor stage, and tumor grade. RESULTS: The mean Cho/water of EC with Ki-67 SI ≤ 40% (2.28 ± 0.93) × 10(−3) was lower than that with Ki-67 SI > 40% (4.08 ± 1.00) × 10(−3) (P < 0.001). The mean Cho/water of EC with deep and superficial myometrial invasion was (3.41 ± 1.26) × 10(−3) and (2.43 ± 1.11) × 10(−3), respectively (P = 0.011). There was no significant difference in Cho/water between type I EC with and without cervical invasioin ([2.68 ± 1.00] × 10(−3) and [2.77 ± 1.28] × 10(−3), P = 0.866). The mean Cho/water of type I EC with and without lymph node metastasis was (4.02 ± 1.90) × 10(−3) and (2.60 ± 1.06) × 10(−3), respectively (P = 0.014). The Cho/water was positively correlated with the Ki-67 SI (r = 0.701, P < 0.001). There were no significant differences in ADC among groups (all P > 0.05). CONCLUSION: MRS is helpful for preoperative assessment of clinicopathological features of type I EC. |
format | Online Article Text |
id | pubmed-9295509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92955092022-07-20 Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer Zhang, Jie Liu, Qingwei Li, Jie Liu, Zhiling Wang, Ximing Li, Na Huang, Zhaoqin Xu, Han BMC Med Imaging Research BACKGROUND: We studied the magnetic resonance spectroscopy (MRS) associations with clinicopathologic features of estrogen-dependent endometrial cancer (type I EC). METHODS: Totally 45 patients with type I EC who underwent preoperative multi-voxel MRS at 3.0 T were enrolled. The mean ratio of the Cho peak integral to the unsuppressed water peak integral (Cho/water) of the tumor was calculated. The Cho/water and apparent diffusion coefficient (ADC) of type I EC with and without local invasion, as well as with different levels of Ki-67 staining index (SI) (≤ 40% and > 40%), were compared. Correlation test was used to examine the relationship of Cho/water, as well as mean ADC, with Ki-67 SI, tumor stage, and tumor grade. RESULTS: The mean Cho/water of EC with Ki-67 SI ≤ 40% (2.28 ± 0.93) × 10(−3) was lower than that with Ki-67 SI > 40% (4.08 ± 1.00) × 10(−3) (P < 0.001). The mean Cho/water of EC with deep and superficial myometrial invasion was (3.41 ± 1.26) × 10(−3) and (2.43 ± 1.11) × 10(−3), respectively (P = 0.011). There was no significant difference in Cho/water between type I EC with and without cervical invasioin ([2.68 ± 1.00] × 10(−3) and [2.77 ± 1.28] × 10(−3), P = 0.866). The mean Cho/water of type I EC with and without lymph node metastasis was (4.02 ± 1.90) × 10(−3) and (2.60 ± 1.06) × 10(−3), respectively (P = 0.014). The Cho/water was positively correlated with the Ki-67 SI (r = 0.701, P < 0.001). There were no significant differences in ADC among groups (all P > 0.05). CONCLUSION: MRS is helpful for preoperative assessment of clinicopathological features of type I EC. BioMed Central 2022-07-18 /pmc/articles/PMC9295509/ /pubmed/35850646 http://dx.doi.org/10.1186/s12880-022-00856-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhang, Jie Liu, Qingwei Li, Jie Liu, Zhiling Wang, Ximing Li, Na Huang, Zhaoqin Xu, Han Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer |
title | Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer |
title_full | Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer |
title_fullStr | Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer |
title_full_unstemmed | Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer |
title_short | Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer |
title_sort | magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295509/ https://www.ncbi.nlm.nih.gov/pubmed/35850646 http://dx.doi.org/10.1186/s12880-022-00856-9 |
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