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Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, development, and plasticity. Evidence suggests that fluctuations in peripheral levels (i.e., plasma or serum) of BDNF are associated with eating behaviors. Nevertheless, the findings are inconsi...

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Autores principales: Shobeiri, Parnian, Bagherieh, Sara, Mirzayi, Parsa, Kalantari, Amirali, Mirmosayyeb, Omid, Teixeira, Antônio L., Rezaei, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295529/
https://www.ncbi.nlm.nih.gov/pubmed/35850718
http://dx.doi.org/10.1186/s40337-022-00630-w
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author Shobeiri, Parnian
Bagherieh, Sara
Mirzayi, Parsa
Kalantari, Amirali
Mirmosayyeb, Omid
Teixeira, Antônio L.
Rezaei, Nima
author_facet Shobeiri, Parnian
Bagherieh, Sara
Mirzayi, Parsa
Kalantari, Amirali
Mirmosayyeb, Omid
Teixeira, Antônio L.
Rezaei, Nima
author_sort Shobeiri, Parnian
collection PubMed
description BACKGROUND: Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, development, and plasticity. Evidence suggests that fluctuations in peripheral levels (i.e., plasma or serum) of BDNF are associated with eating behaviors. Nevertheless, the findings are inconsistent. The purpose of this study is to determine if serum or plasma levels of BDNF are altered in individuals with eating disorders (EDs) compared to controls. METHODS: We conducted a systematic search of the core electronic medical databases from inception to March 2022 and identified observational studies that compared individuals with EDs to controls without EDs on serum or plasma levels of BDNF. R version 4.0.4 was used for all visualizations and calculations. RESULTS: The current meta-analysis comprised 15 studies that fulfilled the inclusion criteria. Subjects with EDs (n = 795) showed lower BDNF levels compared to non-EDs controls (n = 552) (SMD: − 0.49, 95% CI [− 0.89; − 0.08], p-value = 0.01). Moreover, subgroup analysis was conducted based on the specimen (plasma and serum), which revealed no statistically significant difference in the levels of BDNF between the two subgroups (p-value = 0.92). Additionally, meta-regression results revealed that publication year, mean age of the individuals with EDs, NOS scores, and the number of individuals with EDs collectively accounted for 25.99% percent of the existing heterogeneity. CONCLUSION: Lower BDNF levels are associated with EDs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40337-022-00630-w.
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spelling pubmed-92955292022-07-20 Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis Shobeiri, Parnian Bagherieh, Sara Mirzayi, Parsa Kalantari, Amirali Mirmosayyeb, Omid Teixeira, Antônio L. Rezaei, Nima J Eat Disord Review BACKGROUND: Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, development, and plasticity. Evidence suggests that fluctuations in peripheral levels (i.e., plasma or serum) of BDNF are associated with eating behaviors. Nevertheless, the findings are inconsistent. The purpose of this study is to determine if serum or plasma levels of BDNF are altered in individuals with eating disorders (EDs) compared to controls. METHODS: We conducted a systematic search of the core electronic medical databases from inception to March 2022 and identified observational studies that compared individuals with EDs to controls without EDs on serum or plasma levels of BDNF. R version 4.0.4 was used for all visualizations and calculations. RESULTS: The current meta-analysis comprised 15 studies that fulfilled the inclusion criteria. Subjects with EDs (n = 795) showed lower BDNF levels compared to non-EDs controls (n = 552) (SMD: − 0.49, 95% CI [− 0.89; − 0.08], p-value = 0.01). Moreover, subgroup analysis was conducted based on the specimen (plasma and serum), which revealed no statistically significant difference in the levels of BDNF between the two subgroups (p-value = 0.92). Additionally, meta-regression results revealed that publication year, mean age of the individuals with EDs, NOS scores, and the number of individuals with EDs collectively accounted for 25.99% percent of the existing heterogeneity. CONCLUSION: Lower BDNF levels are associated with EDs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40337-022-00630-w. BioMed Central 2022-07-18 /pmc/articles/PMC9295529/ /pubmed/35850718 http://dx.doi.org/10.1186/s40337-022-00630-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Shobeiri, Parnian
Bagherieh, Sara
Mirzayi, Parsa
Kalantari, Amirali
Mirmosayyeb, Omid
Teixeira, Antônio L.
Rezaei, Nima
Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis
title Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis
title_full Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis
title_fullStr Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis
title_full_unstemmed Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis
title_short Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis
title_sort serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (eds): a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295529/
https://www.ncbi.nlm.nih.gov/pubmed/35850718
http://dx.doi.org/10.1186/s40337-022-00630-w
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