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Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer

BACKGROUND: Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death, which leads to the release of tumor antigen and damage-associated molecular patterns. However, this induction often fails t...

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Detalles Bibliográficos
Autores principales:	Ye, Jian, Mills, Bradley N, Qin, Shuyang S, Garrett-Larsen, Jesse, Murphy, Joseph D, Uccello, Taylor P, Han, Booyeon J, Vrooman, Tara G, Johnston, Carl J, Lord, Edith M, Belt, Brian A, Linehan, David C, Gerber, Scott A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295644/ https://www.ncbi.nlm.nih.gov/pubmed/35851308 http://dx.doi.org/10.1136/jitc-2022-004784

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