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Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity

Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively st...

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Detalles Bibliográficos
Autores principales: Tang, Tianyu, Huang, Xing, Zhang, Gang, Liang, Tingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295653/
https://www.ncbi.nlm.nih.gov/pubmed/35851309
http://dx.doi.org/10.1136/jitc-2022-005065
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author Tang, Tianyu
Huang, Xing
Zhang, Gang
Liang, Tingbo
author_facet Tang, Tianyu
Huang, Xing
Zhang, Gang
Liang, Tingbo
author_sort Tang, Tianyu
collection PubMed
description Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy.
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spelling pubmed-92956532022-08-09 Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity Tang, Tianyu Huang, Xing Zhang, Gang Liang, Tingbo J Immunother Cancer Commentary Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy. BMJ Publishing Group 2022-07-14 /pmc/articles/PMC9295653/ /pubmed/35851309 http://dx.doi.org/10.1136/jitc-2022-005065 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.
spellingShingle Commentary
Tang, Tianyu
Huang, Xing
Zhang, Gang
Liang, Tingbo
Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
title Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
title_full Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
title_fullStr Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
title_full_unstemmed Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
title_short Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
title_sort oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295653/
https://www.ncbi.nlm.nih.gov/pubmed/35851309
http://dx.doi.org/10.1136/jitc-2022-005065
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