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Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295653/ https://www.ncbi.nlm.nih.gov/pubmed/35851309 http://dx.doi.org/10.1136/jitc-2022-005065 |
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author | Tang, Tianyu Huang, Xing Zhang, Gang Liang, Tingbo |
author_facet | Tang, Tianyu Huang, Xing Zhang, Gang Liang, Tingbo |
author_sort | Tang, Tianyu |
collection | PubMed |
description | Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy. |
format | Online Article Text |
id | pubmed-9295653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-92956532022-08-09 Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity Tang, Tianyu Huang, Xing Zhang, Gang Liang, Tingbo J Immunother Cancer Commentary Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy. BMJ Publishing Group 2022-07-14 /pmc/articles/PMC9295653/ /pubmed/35851309 http://dx.doi.org/10.1136/jitc-2022-005065 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Commentary Tang, Tianyu Huang, Xing Zhang, Gang Liang, Tingbo Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
title | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
title_full | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
title_fullStr | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
title_full_unstemmed | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
title_short | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
title_sort | oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295653/ https://www.ncbi.nlm.nih.gov/pubmed/35851309 http://dx.doi.org/10.1136/jitc-2022-005065 |
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