Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital

Around 450 cases of acute severe hepatitis of unknown origin in children have been reported in 21 countries and region globally since April 2022, which has exceeded the past annual incidences of related regions, and has aroused wide concern. Affected patients were predominantly children under 16 yea...

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Autores principales: Cao, Wei, Li, Zhenghong, Zhu, Huadong, Zhou, Xiang, Yang, Qiwen, Han, Yang, Liu, Jihai, Chang, Qing, Li, Taisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Consensus and Guideline
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295933/
https://www.ncbi.nlm.nih.gov/pubmed/37520111
http://dx.doi.org/10.1097/ID9.0000000000000061
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author Cao, Wei
Li, Zhenghong
Zhu, Huadong
Zhou, Xiang
Yang, Qiwen
Han, Yang
Liu, Jihai
Chang, Qing
Li, Taisheng
author_facet Cao, Wei
Li, Zhenghong
Zhu, Huadong
Zhou, Xiang
Yang, Qiwen
Han, Yang
Liu, Jihai
Chang, Qing
Li, Taisheng
author_sort Cao, Wei
collection PubMed
description Around 450 cases of acute severe hepatitis of unknown origin in children have been reported in 21 countries and region globally since April 2022, which has exceeded the past annual incidences of related regions, and has aroused wide concern. Affected patients were predominantly children under 16 years of age, presented with symptoms of acute hepatitis with markedly elevated liver enzymes, and had been ruled out of common viral infections such as hepatitis A, B, C, D, and E. Similar cases have not been reported in China yet. However, considering that the severe acute hepatitis has involved worldwide areas, still with unknown origin, and incidences of severity is relatively high, we formulated this recommendation to standardize diagnosis and treatment of acute severe hepatitis of unknown origin in Peking Union Medical College Hospital, to get fully prepared to the possible public health events.
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spelling pubmed-92959332022-08-03 Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital Cao, Wei Li, Zhenghong Zhu, Huadong Zhou, Xiang Yang, Qiwen Han, Yang Liu, Jihai Chang, Qing Li, Taisheng Infectious Diseases & Immunity Consensus and Guideline Around 450 cases of acute severe hepatitis of unknown origin in children have been reported in 21 countries and region globally since April 2022, which has exceeded the past annual incidences of related regions, and has aroused wide concern. Affected patients were predominantly children under 16 years of age, presented with symptoms of acute hepatitis with markedly elevated liver enzymes, and had been ruled out of common viral infections such as hepatitis A, B, C, D, and E. Similar cases have not been reported in China yet. However, considering that the severe acute hepatitis has involved worldwide areas, still with unknown origin, and incidences of severity is relatively high, we formulated this recommendation to standardize diagnosis and treatment of acute severe hepatitis of unknown origin in Peking Union Medical College Hospital, to get fully prepared to the possible public health events. Lippincott Williams & Wilkins 2022-06-28 /pmc/articles/PMC9295933/ /pubmed/37520111 http://dx.doi.org/10.1097/ID9.0000000000000061 Text en Copyright © 2022 The Chinese Medical Association, published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Consensus and Guideline
Cao, Wei
Li, Zhenghong
Zhu, Huadong
Zhou, Xiang
Yang, Qiwen
Han, Yang
Liu, Jihai
Chang, Qing
Li, Taisheng
Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital
title Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital
title_full Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital
title_fullStr Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital
title_full_unstemmed Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital
title_short Diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital
title_sort diagnosis and clinical management of acute severe hepatitis of unknown origin: operational recommendation of peking union medical college hospital
topic Consensus and Guideline
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295933/
https://www.ncbi.nlm.nih.gov/pubmed/37520111
http://dx.doi.org/10.1097/ID9.0000000000000061
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