HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington’s disease pathogenesis

Perturbation of huntingtin (HTT)’s physiological function is one postulated pathogenic factor in Huntington’s disease (HD). However, little is known how HTT is regulated in vivo. In a proteomic study, we isolated a novel ~40kDa protein as a strong binding partner of Drosophila HTT and demonstrated i...

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Detalles Bibliográficos
Autores principales: Xu, Shiyu, Li, Gang, Ye, Xin, Chen, Dongsheng, Chen, Zhihua, Xu, Zhen, Daniele, Moretti, Tambone, Sara, Ceccacci, Alessandra, Tomei, Licia, Ye, Lili, Yu, Yue, Solbach, Amanda, Farmer, Stephen M., Stimming, Erin Furr, McAllister, George, Marchionini, Deanna M., Zhang, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295956/
https://www.ncbi.nlm.nih.gov/pubmed/35853002
http://dx.doi.org/10.1371/journal.pgen.1010302

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