Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci

Chromosomal translocations frequently promote carcinogenesis by producing gain-of-function fusion proteins. Recent studies have identified highly recurrent chromosomal translocations in patients with endometrial stromal sarcomas (ESSs) and ossifying fibromyxoid tumors (OFMTs), leading to an in-frame...

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Detalles Bibliográficos
Autores principales: Sudarshan, Deepthi, Avvakumov, Nikita, Lalonde, Marie-Eve, Alerasool, Nader, Joly-Beauparlant, Charles, Jacquet, Karine, Mameri, Amel, Lambert, Jean-Philippe, Rousseau, Justine, Lachance, Catherine, Paquet, Eric, Herrmann, Lara, Thonta Setty, Samarth, Loehr, Jeremy, Bernardini, Marcus Q., Rouzbahman, Marjan, Gingras, Anne-Claude, Coulombe, Benoit, Droit, Arnaud, Taipale, Mikko, Doyon, Yannick, Côté, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296003/
https://www.ncbi.nlm.nih.gov/pubmed/35710139
http://dx.doi.org/10.1101/gad.348982.121

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