Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus

How distal regulatory elements control gene transcription and chromatin topology is not clearly defined, yet these processes are closely linked in lineage specification during development. Through allele-specific genome editing and chromatin interaction analyses of the Sox2 locus in mouse embryonic...

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Detalles Bibliográficos
Autores principales: Taylor, Tiegh, Sikorska, Natalia, Shchuka, Virlana M., Chahar, Sanjay, Ji, Chenfan, Macpherson, Neil N., Moorthy, Sakthi D., de Kort, Marit A.C., Mullany, Shanelle, Khader, Nawrah, Gillespie, Zoe E., Langroudi, Lida, Tobias, Ian C., Lenstra, Tineke L., Mitchell, Jennifer A., Sexton, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296009/
https://www.ncbi.nlm.nih.gov/pubmed/35710138
http://dx.doi.org/10.1101/gad.349489.122

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