Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo

Knockdown of GH receptor (GHR) in melanoma cells in vitro downregulates ATP-binding cassette-containing (ABC) transporters and sensitizes them to anti-cancer drug treatments. Here we aimed to determine whether a GHR antagonist (GHRA) could control cancer growth by sensitizing tumors to therapy throu...

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Detalles Bibliográficos
Autores principales: Basu, Reetobrata, Qian, Yanrong, Mathes, Samuel, Terry, Joseph, Arnett, Nathan, Riddell, Trent, Stevens, Austin, Funk, Kevin, Bell, Stephen, Bokal, Zac, Batten, Courtney, Smith, Cole, Mendez-Gibson, Isaac, Duran-Ortiz, Silvana, Lach, Grace, Mora-Criollo, Patricia Alexandra, Kulkarni, Prateek, Davis, Emily, Teaford, Elizabeth, Berryman, Darlene E., List, Edward O., Neggers, Sebastian, Kopchick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296106/
https://www.ncbi.nlm.nih.gov/pubmed/35865483
http://dx.doi.org/10.3389/fonc.2022.936145

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