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Complete mapping of disulfide linkages for etanercept products by multi-enzyme digestion coupled with LC-MS/MS using multi-fragmentations including CID and ETD

The disulfide linkages of two etanercept products, Enbrel® (innovator drug) and TuNEX®, were characterized and compared using a multi-fragmentation approach consisting of electron transfer dissociation (ETD) and collision induced dissociation (CID) in combination with multi-enzyme digestion protocol...

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Detalles Bibliográficos
Autores principales:	Huang, Li-Juan, Chiang, Chia-Wang, Chen, Shun-Li, Wei, Shih-Yao, Chen, Shu-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taiwan Food and Drug Administration 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296193/ https://www.ncbi.nlm.nih.gov/pubmed/30987725 http://dx.doi.org/10.1016/j.jfda.2018.11.007

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