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Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry
Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taiwan Food and Drug Administration
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296206/ https://www.ncbi.nlm.nih.gov/pubmed/30987714 http://dx.doi.org/10.1016/j.jfda.2018.09.002 |
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author | Ng, Tsz-Tsun So, Pui-Kin Hu, Bin Yao, Zhong-Ping |
author_facet | Ng, Tsz-Tsun So, Pui-Kin Hu, Bin Yao, Zhong-Ping |
author_sort | Ng, Tsz-Tsun |
collection | PubMed |
description | Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standards, and those of MDMA and cocaine could fulfill some of the requirements. The linear range, accuracy and precision for quantitation of the drugs were generally satisfactory, except for THC for which the analytical performance still needs to be improved. Analysis of one sample could typically be completed within minutes. These results indicated that WT-ESI-MS could be used for rapid screening of drugs-of-abuse in urine, oral fluid as well as other body fluids. |
format | Online Article Text |
id | pubmed-9296206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taiwan Food and Drug Administration |
record_format | MEDLINE/PubMed |
spelling | pubmed-92962062022-08-09 Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry Ng, Tsz-Tsun So, Pui-Kin Hu, Bin Yao, Zhong-Ping J Food Drug Anal Original Article Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standards, and those of MDMA and cocaine could fulfill some of the requirements. The linear range, accuracy and precision for quantitation of the drugs were generally satisfactory, except for THC for which the analytical performance still needs to be improved. Analysis of one sample could typically be completed within minutes. These results indicated that WT-ESI-MS could be used for rapid screening of drugs-of-abuse in urine, oral fluid as well as other body fluids. Taiwan Food and Drug Administration 2018-10-01 /pmc/articles/PMC9296206/ /pubmed/30987714 http://dx.doi.org/10.1016/j.jfda.2018.09.002 Text en © 2019 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Original Article Ng, Tsz-Tsun So, Pui-Kin Hu, Bin Yao, Zhong-Ping Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry |
title | Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry |
title_full | Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry |
title_fullStr | Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry |
title_full_unstemmed | Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry |
title_short | Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry |
title_sort | rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296206/ https://www.ncbi.nlm.nih.gov/pubmed/30987714 http://dx.doi.org/10.1016/j.jfda.2018.09.002 |
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