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Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care

The unintentional ingestion of toxic compounds in herbs is not uncommon in many parts of the world. To provide timely and life-saving care in the emergency department, it is essential to develop a point-of-care analytical method that can rapidly identify these toxins in herbs. Since electrospray las...

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Autores principales: Su, Hung, Liu, Kuan-Ting, Chen, Bai-Hsiun, Lin, Yen-Ping, Jiang, Yu-Min, Tsai, Yi-Hong, Chang, Fang-Rong, Shiea, Jentaie, Lee, Chi-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296212/
https://www.ncbi.nlm.nih.gov/pubmed/30987713
http://dx.doi.org/10.1016/j.jfda.2018.11.001
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author Su, Hung
Liu, Kuan-Ting
Chen, Bai-Hsiun
Lin, Yen-Ping
Jiang, Yu-Min
Tsai, Yi-Hong
Chang, Fang-Rong
Shiea, Jentaie
Lee, Chi-Wei
author_facet Su, Hung
Liu, Kuan-Ting
Chen, Bai-Hsiun
Lin, Yen-Ping
Jiang, Yu-Min
Tsai, Yi-Hong
Chang, Fang-Rong
Shiea, Jentaie
Lee, Chi-Wei
author_sort Su, Hung
collection PubMed
description The unintentional ingestion of toxic compounds in herbs is not uncommon in many parts of the world. To provide timely and life-saving care in the emergency department, it is essential to develop a point-of-care analytical method that can rapidly identify these toxins in herbs. Since electrospray laser desorption ionization mass spectrometry (ELDI/MS) has been successfully used to characterize non-volatile chemical compounds without sample preparation, it was used to identify toxic herbal compounds in this study. The herbal toxins were collected either by sweeping a metallic probe across the surface of a freshly cut herb section or by directly sampling extracts of ground herbal powder. The analytes on the probe were then desorbed, ionized and detected using ELDI/MS, wherein analysis of the herbal toxins was completed within 30 s. This approach allows for the rapid morphological recognition of herbs and early point-of-care identification of herbal toxins for emergency management and is promising in providing important toxicological information to ensure appropriate medical treatment.
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spelling pubmed-92962122022-08-09 Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care Su, Hung Liu, Kuan-Ting Chen, Bai-Hsiun Lin, Yen-Ping Jiang, Yu-Min Tsai, Yi-Hong Chang, Fang-Rong Shiea, Jentaie Lee, Chi-Wei J Food Drug Anal Original Article The unintentional ingestion of toxic compounds in herbs is not uncommon in many parts of the world. To provide timely and life-saving care in the emergency department, it is essential to develop a point-of-care analytical method that can rapidly identify these toxins in herbs. Since electrospray laser desorption ionization mass spectrometry (ELDI/MS) has been successfully used to characterize non-volatile chemical compounds without sample preparation, it was used to identify toxic herbal compounds in this study. The herbal toxins were collected either by sweeping a metallic probe across the surface of a freshly cut herb section or by directly sampling extracts of ground herbal powder. The analytes on the probe were then desorbed, ionized and detected using ELDI/MS, wherein analysis of the herbal toxins was completed within 30 s. This approach allows for the rapid morphological recognition of herbs and early point-of-care identification of herbal toxins for emergency management and is promising in providing important toxicological information to ensure appropriate medical treatment. Taiwan Food and Drug Administration 2019-01-03 /pmc/articles/PMC9296212/ /pubmed/30987713 http://dx.doi.org/10.1016/j.jfda.2018.11.001 Text en © 2019 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Su, Hung
Liu, Kuan-Ting
Chen, Bai-Hsiun
Lin, Yen-Ping
Jiang, Yu-Min
Tsai, Yi-Hong
Chang, Fang-Rong
Shiea, Jentaie
Lee, Chi-Wei
Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
title Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
title_full Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
title_fullStr Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
title_full_unstemmed Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
title_short Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
title_sort rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296212/
https://www.ncbi.nlm.nih.gov/pubmed/30987713
http://dx.doi.org/10.1016/j.jfda.2018.11.001
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