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Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report

Objective  Technetium-99m labeled prostate-specific membrane antigen (PSMA) single-photon emission computed tomography/computed tomography (SPECT/CT) is a suitable alternative to prostate-specific membrane antigen-positron emission tomography (PSMA-PET) imaging. However, the availability of SPECT/CT...

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Autores principales: Orunmuyi, A.T., Oladeji, A.A., Azodoh, E.U., Omisanjo, O.A., Olapade-Olaopa, E.O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296248/
https://www.ncbi.nlm.nih.gov/pubmed/35865161
http://dx.doi.org/10.1055/s-0042-1750336
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author Orunmuyi, A.T.
Oladeji, A.A.
Azodoh, E.U.
Omisanjo, O.A.
Olapade-Olaopa, E.O.
author_facet Orunmuyi, A.T.
Oladeji, A.A.
Azodoh, E.U.
Omisanjo, O.A.
Olapade-Olaopa, E.O.
author_sort Orunmuyi, A.T.
collection PubMed
description Objective  Technetium-99m labeled prostate-specific membrane antigen (PSMA) single-photon emission computed tomography/computed tomography (SPECT/CT) is a suitable alternative to prostate-specific membrane antigen-positron emission tomography (PSMA-PET) imaging. However, the availability of SPECT/CT in many developing countries is limited. Materials and Methods  To evaluate the utility of planar (99m) Tc-PSMA in the absence of SPECT/CT, we compared planar (99m) Tc-PSMA and routine bone scan imaging in low-, intermediate-, and high-risk prostate cancer in five patients with histologically confirmed prostate cancer who had both scans within a period of less than 4 days. The mean age of patients was 66.8 ± 5.24, and the median prostate-specific antigen level was 175 ng/mL (range: 0–778 ng/mL). Results  Planar (99m) Tc-PSMA scan provided no additional benefit over bone scans in the low-risk prostate cancer cases. In the cases with intermediate-risk prostate cancers, planar (99m) Tc-PSMA indicated complete and partial response to treatment in oligometastatic and widespread metastatic disease, respectively. In one patient with high-risk prostate cancer, planar (99m) Tc-PSMA detected additional skeletal lesions that were not seen on bone scan. Conclusion  In the absence of SPECT/CT, planar (99m) Tc-PSMA was useful for confirming extent of disease in treated intermediate- and high-risk prostate cancer. It showed little value in low-risk prostate cancer, especially when bone scan is normal. It was particularly useful for treatment response assessment in oligometastatic disease, and its utility should be further explored.
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spelling pubmed-92962482022-07-20 Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report Orunmuyi, A.T. Oladeji, A.A. Azodoh, E.U. Omisanjo, O.A. Olapade-Olaopa, E.O. World J Nucl Med Objective  Technetium-99m labeled prostate-specific membrane antigen (PSMA) single-photon emission computed tomography/computed tomography (SPECT/CT) is a suitable alternative to prostate-specific membrane antigen-positron emission tomography (PSMA-PET) imaging. However, the availability of SPECT/CT in many developing countries is limited. Materials and Methods  To evaluate the utility of planar (99m) Tc-PSMA in the absence of SPECT/CT, we compared planar (99m) Tc-PSMA and routine bone scan imaging in low-, intermediate-, and high-risk prostate cancer in five patients with histologically confirmed prostate cancer who had both scans within a period of less than 4 days. The mean age of patients was 66.8 ± 5.24, and the median prostate-specific antigen level was 175 ng/mL (range: 0–778 ng/mL). Results  Planar (99m) Tc-PSMA scan provided no additional benefit over bone scans in the low-risk prostate cancer cases. In the cases with intermediate-risk prostate cancers, planar (99m) Tc-PSMA indicated complete and partial response to treatment in oligometastatic and widespread metastatic disease, respectively. In one patient with high-risk prostate cancer, planar (99m) Tc-PSMA detected additional skeletal lesions that were not seen on bone scan. Conclusion  In the absence of SPECT/CT, planar (99m) Tc-PSMA was useful for confirming extent of disease in treated intermediate- and high-risk prostate cancer. It showed little value in low-risk prostate cancer, especially when bone scan is normal. It was particularly useful for treatment response assessment in oligometastatic disease, and its utility should be further explored. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-06-28 /pmc/articles/PMC9296248/ /pubmed/35865161 http://dx.doi.org/10.1055/s-0042-1750336 Text en World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Orunmuyi, A.T.
Oladeji, A.A.
Azodoh, E.U.
Omisanjo, O.A.
Olapade-Olaopa, E.O.
Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report
title Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report
title_full Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report
title_fullStr Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report
title_full_unstemmed Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report
title_short Planar (99m) Tc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report
title_sort planar (99m) tc-psma imaging of prostate cancer in a low-resource setting: a series report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296248/
https://www.ncbi.nlm.nih.gov/pubmed/35865161
http://dx.doi.org/10.1055/s-0042-1750336
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