KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway

Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of our study showed that KIF26B is highly expres...

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Autores principales: Liu, Yajun, Zhang, Xi, Pan, Ruihan, Liang, Xiaolong, Liu, Qichang, Yang, Chao, Li, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296275/
https://www.ncbi.nlm.nih.gov/pubmed/35866054
http://dx.doi.org/10.1155/2022/2552397
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author Liu, Yajun
Zhang, Xi
Pan, Ruihan
Liang, Xiaolong
Liu, Qichang
Yang, Chao
Li, Xu
author_facet Liu, Yajun
Zhang, Xi
Pan, Ruihan
Liang, Xiaolong
Liu, Qichang
Yang, Chao
Li, Xu
author_sort Liu, Yajun
collection PubMed
description Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of our study showed that KIF26B is highly expressed in medulloblastoma, and its high expression is associated with a high clinical stage. Knockdown the expression of KIF26B could significantly impair the proliferation and migration of medulloblastoma cells. KIF26B promotes the malignant progression of medulloblastoma by affecting the expression of phosphorylation of key proteins in the PI3K/AKT signaling pathway. With the help of 740 Y-P, activating the pi3k signaling pathway can partially rescue the phenotype. Therefore, our experimental results suggest that KIF26B is a potential target for medulloblastoma.
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spelling pubmed-92962752022-07-20 KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway Liu, Yajun Zhang, Xi Pan, Ruihan Liang, Xiaolong Liu, Qichang Yang, Chao Li, Xu Anal Cell Pathol (Amst) Research Article Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of our study showed that KIF26B is highly expressed in medulloblastoma, and its high expression is associated with a high clinical stage. Knockdown the expression of KIF26B could significantly impair the proliferation and migration of medulloblastoma cells. KIF26B promotes the malignant progression of medulloblastoma by affecting the expression of phosphorylation of key proteins in the PI3K/AKT signaling pathway. With the help of 740 Y-P, activating the pi3k signaling pathway can partially rescue the phenotype. Therefore, our experimental results suggest that KIF26B is a potential target for medulloblastoma. Hindawi 2022-07-12 /pmc/articles/PMC9296275/ /pubmed/35866054 http://dx.doi.org/10.1155/2022/2552397 Text en Copyright © 2022 Yajun Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Yajun
Zhang, Xi
Pan, Ruihan
Liang, Xiaolong
Liu, Qichang
Yang, Chao
Li, Xu
KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway
title KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway
title_full KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway
title_fullStr KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway
title_full_unstemmed KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway
title_short KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway
title_sort kif26b is overexpressed in medulloblastoma and promotes malignant progression by activating the pi3k/akt pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296275/
https://www.ncbi.nlm.nih.gov/pubmed/35866054
http://dx.doi.org/10.1155/2022/2552397
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