Cargando…
Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer
OBJECTIVE: To assess the clinical efficacy of acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy in progressive gastric cancer. METHODS: In this randomized, double-blind, controlled clinical trial, 70 patients with advanced gastric cancer receiving radio-chemo...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296292/ https://www.ncbi.nlm.nih.gov/pubmed/35865087 http://dx.doi.org/10.1155/2022/6156585 |
_version_ | 1784750240317833216 |
---|---|
author | Miao, Xiaomei Wu, Hongying Liu, Yan Zhang, Shu Li, Chaohui Hao, Jie |
author_facet | Miao, Xiaomei Wu, Hongying Liu, Yan Zhang, Shu Li, Chaohui Hao, Jie |
author_sort | Miao, Xiaomei |
collection | PubMed |
description | OBJECTIVE: To assess the clinical efficacy of acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy in progressive gastric cancer. METHODS: In this randomized, double-blind, controlled clinical trial, 70 patients with advanced gastric cancer receiving radio-chemotherapy between May 2018 and June 2020 were assessed for eligibility in our institution and recruited. They were assigned via the random number table method at a ratio of 1 : 1 to receive either neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy (control group) or acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy (intervention group). The outcome measures included symptom mitigation, quality of life, and traditional Chinese medicine (TCM) symptom scores. RESULTS: The two groups showed similar results in abdominal circumference, intraabdominal pressure, and bowel sounds before treatment (P > 0.05). Acupuncture plus conventional treatment was associated with better mitigation on intraabdominal pressure (11.08 ± 1.37 vs. 12.17 ± 2.68) and bowel sounds (4 [3, 4] vs. 3 [3, 4]) versus conventional treatment alone (P < 0.05). No statistically significant difference in TCM symptom scores was observed between the two groups before treatment (P > 0.05). Acupuncture plus conventional treatment resulted in a lower TCM symptom score (24.63 ± 4.56 points) versus conventional treatment (31.17 ± 4.91 points) (P < 0.05). The eligible patients given acupuncture showed significantly higher scores of physical function, role function, emotional function, cognitive function, and social function (81.52 ± 5.37, 88.17 ± 5.17, 85.15 ± 6.71, 78.45 ± 5.85, and 80.98 ± 7.14) versus those without acupuncture (52.98 ± 8.23, 69.87 ± 5.54, 68.24 ± 9.22, 61.34 ± 6.27, and 64.79 ± 6.89) (P < 0.05). CONCLUSION: Acupuncture is effective in the recovery of acute toxicity after radio-chemotherapy for patients with advanced gastric cancer, which provides a certain reference for clinical treatment and is worthy of application and promotion. |
format | Online Article Text |
id | pubmed-9296292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-92962922022-07-20 Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer Miao, Xiaomei Wu, Hongying Liu, Yan Zhang, Shu Li, Chaohui Hao, Jie J Oncol Research Article OBJECTIVE: To assess the clinical efficacy of acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy in progressive gastric cancer. METHODS: In this randomized, double-blind, controlled clinical trial, 70 patients with advanced gastric cancer receiving radio-chemotherapy between May 2018 and June 2020 were assessed for eligibility in our institution and recruited. They were assigned via the random number table method at a ratio of 1 : 1 to receive either neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy (control group) or acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy (intervention group). The outcome measures included symptom mitigation, quality of life, and traditional Chinese medicine (TCM) symptom scores. RESULTS: The two groups showed similar results in abdominal circumference, intraabdominal pressure, and bowel sounds before treatment (P > 0.05). Acupuncture plus conventional treatment was associated with better mitigation on intraabdominal pressure (11.08 ± 1.37 vs. 12.17 ± 2.68) and bowel sounds (4 [3, 4] vs. 3 [3, 4]) versus conventional treatment alone (P < 0.05). No statistically significant difference in TCM symptom scores was observed between the two groups before treatment (P > 0.05). Acupuncture plus conventional treatment resulted in a lower TCM symptom score (24.63 ± 4.56 points) versus conventional treatment (31.17 ± 4.91 points) (P < 0.05). The eligible patients given acupuncture showed significantly higher scores of physical function, role function, emotional function, cognitive function, and social function (81.52 ± 5.37, 88.17 ± 5.17, 85.15 ± 6.71, 78.45 ± 5.85, and 80.98 ± 7.14) versus those without acupuncture (52.98 ± 8.23, 69.87 ± 5.54, 68.24 ± 9.22, 61.34 ± 6.27, and 64.79 ± 6.89) (P < 0.05). CONCLUSION: Acupuncture is effective in the recovery of acute toxicity after radio-chemotherapy for patients with advanced gastric cancer, which provides a certain reference for clinical treatment and is worthy of application and promotion. Hindawi 2022-07-12 /pmc/articles/PMC9296292/ /pubmed/35865087 http://dx.doi.org/10.1155/2022/6156585 Text en Copyright © 2022 Xiaomei Miao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Miao, Xiaomei Wu, Hongying Liu, Yan Zhang, Shu Li, Chaohui Hao, Jie Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer |
title | Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer |
title_full | Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer |
title_fullStr | Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer |
title_full_unstemmed | Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer |
title_short | Clinical Efficacy of Acupuncture on Neoadjuvant Chemotherapy with Capecitabine plus Paclitaxel and Radiotherapy in Progressive Gastric Cancer |
title_sort | clinical efficacy of acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy in progressive gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296292/ https://www.ncbi.nlm.nih.gov/pubmed/35865087 http://dx.doi.org/10.1155/2022/6156585 |
work_keys_str_mv | AT miaoxiaomei clinicalefficacyofacupunctureonneoadjuvantchemotherapywithcapecitabinepluspaclitaxelandradiotherapyinprogressivegastriccancer AT wuhongying clinicalefficacyofacupunctureonneoadjuvantchemotherapywithcapecitabinepluspaclitaxelandradiotherapyinprogressivegastriccancer AT liuyan clinicalefficacyofacupunctureonneoadjuvantchemotherapywithcapecitabinepluspaclitaxelandradiotherapyinprogressivegastriccancer AT zhangshu clinicalefficacyofacupunctureonneoadjuvantchemotherapywithcapecitabinepluspaclitaxelandradiotherapyinprogressivegastriccancer AT lichaohui clinicalefficacyofacupunctureonneoadjuvantchemotherapywithcapecitabinepluspaclitaxelandradiotherapyinprogressivegastriccancer AT haojie clinicalefficacyofacupunctureonneoadjuvantchemotherapywithcapecitabinepluspaclitaxelandradiotherapyinprogressivegastriccancer |