α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice

Pathogenic α-synuclein (α-syn) is a prion-like protein that drives the pathogenesis of Lewy Body Dementia (LBD) and Parkinson’s Disease (PD). To target pathogenic α-syn preformed fibrils (PFF), here we designed extracellular disulfide bond-free synthetic nanobody libraries in yeast. Following select...

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Detalles Bibliográficos
Autores principales: Butler, Yemima R., Liu, Yuqing, Kumbhar, Ramhari, Zhao, Peiran, Gadhave, Kundlik, Wang, Ning, Li, Yanmei, Mao, Xiaobo, Wang, Wenjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296447/
https://www.ncbi.nlm.nih.gov/pubmed/35853942
http://dx.doi.org/10.1038/s41467-022-31787-2

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