Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Histone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysregulation of histone acetylation can contribute to tumorigenesis and metastasis. Using inducible cre-recombinase and CRISPR/Cas9-mediated deletion, we investigated the role...

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Detalles Bibliográficos
Autores principales: Wichmann, Johannes, Pitt, Catherine, Eccles, Samantha, Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., May, Rose, Allan, Elizabeth, Wilcox, Stephen, Herold, Marco J., Smyth, Gordon K., Monahan, Brendon J., Thomas, Tim, Voss, Anne K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296491/
https://www.ncbi.nlm.nih.gov/pubmed/35853868
http://dx.doi.org/10.1038/s41419-022-05055-6

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