LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease

Leucine-rich repeat kinase 2 (LRRK2) is a kinase involved in different cellular functions, including autophagy, endolysosomal pathways, and immune function. Mutations in LRRK2 cause autosomal-dominant forms of Parkinson’s disease (PD). Heterozygous mutations in GBA1, the gene encoding the lysosomal...

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Detalles Bibliográficos
Autores principales: Kedariti, Maria, Frattini, Emanuele, Baden, Pascale, Cogo, Susanna, Civiero, Laura, Ziviani, Elena, Zilio, Gianluca, Bertoli, Federico, Aureli, Massimo, Kaganovich, Alice, Cookson, Mark R., Stefanis, Leonidas, Surface, Matthew, Deleidi, Michela, Di Fonzo, Alessio, Alcalay, Roy N., Rideout, Hardy, Greggio, Elisa, Plotegher, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296523/
https://www.ncbi.nlm.nih.gov/pubmed/35853899
http://dx.doi.org/10.1038/s41531-022-00354-3

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