An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2‐Oxoglutarate‐Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin

The biosynthesis of the natural product dehydrofosmidomycin involves an unusual transformation in which 2‐(trimethylamino)ethylphosphonate is rearranged, desaturated and demethylated by the enzyme DfmD, a divergent member of the 2‐oxoglutarate‐dependent dioxygenase superfamily. Although other member...

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Detalles Bibliográficos
Autores principales: Parkinson, Elizabeth I., Lakkis, Hani G., Alwali, Amir A., Metcalf, Mary Elizabeth M., Modi, Ramya, Metcalf, William W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296572/
https://www.ncbi.nlm.nih.gov/pubmed/35588368
http://dx.doi.org/10.1002/anie.202206173

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