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Un-biased housekeeping gene panel selection for high-validity gene expression analysis
Differential gene expression normalised to a single housekeeping (HK) is used to identify disease mechanisms and therapeutic targets. HK gene selection is often arbitrary, potentially introducing systematic error and discordant results. Here we examine these risks in a disease model of brain hypoxia...
Autores principales: | Casas, Ana I., Hassan, Ahmed A., Manz, Quirin, Wiwie, Christian, Kleikers, Pamela, Egea, Javier, López, Manuela G., List, Markus, Baumbach, Jan, Schmidt, Harald H. H. W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296577/ https://www.ncbi.nlm.nih.gov/pubmed/35853974 http://dx.doi.org/10.1038/s41598-022-15989-8 |
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