Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

Lung cancer is the leading cause of cancer-related deaths worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous-cell lung cancer (SQCLC). Highly selective tyrosine kinase inhibitors have been...

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Detalles Bibliográficos
Autores principales: Elakad, Omar, Häupl, Björn, Labitzky, Vera, Yao, Sha, Küffer, Stefan, von Hammerstein-Equord, Alexander, Danner, Bernhard C., Jücker, Manfred, Urlaub, Henning, Lange, Tobias, Ströbel, Philipp, Oellerich, Thomas, Bohnenberger, Hanibal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296622/
https://www.ncbi.nlm.nih.gov/pubmed/35853934
http://dx.doi.org/10.1038/s41698-022-00296-2

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