A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection

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SARS-CoV-2 hijacks the host cell transcriptional machinery to induce a phenotypic state amenable to its replication. Here we show that analysis of Master Regulator proteins representing mechanistic determinants of the gene expression signature induced by SARS-CoV-2 in infected cells revealed coordin...

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Detalles Bibliográficos
Autores principales: Laise, Pasquale, Stanifer, Megan L., Bosker, Gideon, Sun, Xiaoyun, Triana, Sergio, Doldan, Patricio, La Manna, Federico, De Menna, Marta, Realubit, Ronald B., Pampou, Sergey, Karan, Charles, Alexandrov, Theodore, Kruithof-de Julio, Marianna, Califano, Andrea, Boulant, Steeve, Alvarez, Mariano J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296638/
https://www.ncbi.nlm.nih.gov/pubmed/35854100
http://dx.doi.org/10.1038/s42003-022-03663-8
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