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Multiple mechanisms underlie reduced potassium conductance in the p.T1019PfsX38 variant of hERG
Long QT syndrome type II (LQT2) is caused by loss‐of‐function mutations in the hERG K(+) channel, leading to increased incidence of cardiac arrest and sudden death. Many genetic variants have been reported in the hERG gene with various consequences on channel expression, permeation, and gating. Only...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296870/ https://www.ncbi.nlm.nih.gov/pubmed/35854468 http://dx.doi.org/10.14814/phy2.15341 |