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Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer
PURPOSE: The clinical significance of body mass index (BMI) on long-term outcomes has not been extensively investigated in Asian patients with colorectal cancer (CRC). This study aims to describe the association between BMI and survival, plus providing BMI cutoff value for predicting prognosis in CR...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296949/ https://www.ncbi.nlm.nih.gov/pubmed/34665954 http://dx.doi.org/10.4143/crt.2021.656 |
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author | Lee, Sangwon Lee, Dong Hee Lee, Jae-Hoon Shin, Su-Jin Lee, Hye Sun Park, Eun Jung Baik, Seung Hyuk Lee, Kang Young Kang, Jeonghyun |
author_facet | Lee, Sangwon Lee, Dong Hee Lee, Jae-Hoon Shin, Su-Jin Lee, Hye Sun Park, Eun Jung Baik, Seung Hyuk Lee, Kang Young Kang, Jeonghyun |
author_sort | Lee, Sangwon |
collection | PubMed |
description | PURPOSE: The clinical significance of body mass index (BMI) on long-term outcomes has not been extensively investigated in Asian patients with colorectal cancer (CRC). This study aims to describe the association between BMI and survival, plus providing BMI cutoff value for predicting prognosis in CRC patients. MATERIALS AND METHODS: A total of 1,182 patients who had undergone surgery for stage I–III CRC from June 2004 to February 2014 were included. BMI was categorized into four groups based on the recommendation for Asian ethnicity. The optimal BMI cutoff value was determined to maximize overall survival (OS) difference. RESULTS: In multivariable analysis, underweight BMI was significantly associated with poor OS (hazard ratio [HR], 2.38; 95% confidence interval [CI], 1.55 to 3.71; p < 0.001) and obese BMI was associated with better OS (HR, 0.72; 95% CI, 0.53 to 0.97; p=0.036) compared with the normal BMI. Overweight and obese BMI were associated with better recurrence-free survival (HR, 0.64; 95% CI, 0.42 to 0.99; p=0.046 and HR, 0.58; 95% CI, 0.38 to 0.89; p=0.014, respectively) compared with the normal BMI group. BMI cutoff value was 20.44 kg/m(2). Adding the BMI cutoff value to cancer staging could increase discriminatory performance in terms of integrated area under the curve and Harrell’s concordance index. CONCLUSION: Compared to normal BMI, underweight BMI was associated with poor survival whereas obese BMI was associated with better survival. BMI cutoff value of 20.44 kg/m(2) is a useful discriminator in Asian patients with CRC. |
format | Online Article Text |
id | pubmed-9296949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-92969492022-07-20 Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer Lee, Sangwon Lee, Dong Hee Lee, Jae-Hoon Shin, Su-Jin Lee, Hye Sun Park, Eun Jung Baik, Seung Hyuk Lee, Kang Young Kang, Jeonghyun Cancer Res Treat Original Article PURPOSE: The clinical significance of body mass index (BMI) on long-term outcomes has not been extensively investigated in Asian patients with colorectal cancer (CRC). This study aims to describe the association between BMI and survival, plus providing BMI cutoff value for predicting prognosis in CRC patients. MATERIALS AND METHODS: A total of 1,182 patients who had undergone surgery for stage I–III CRC from June 2004 to February 2014 were included. BMI was categorized into four groups based on the recommendation for Asian ethnicity. The optimal BMI cutoff value was determined to maximize overall survival (OS) difference. RESULTS: In multivariable analysis, underweight BMI was significantly associated with poor OS (hazard ratio [HR], 2.38; 95% confidence interval [CI], 1.55 to 3.71; p < 0.001) and obese BMI was associated with better OS (HR, 0.72; 95% CI, 0.53 to 0.97; p=0.036) compared with the normal BMI. Overweight and obese BMI were associated with better recurrence-free survival (HR, 0.64; 95% CI, 0.42 to 0.99; p=0.046 and HR, 0.58; 95% CI, 0.38 to 0.89; p=0.014, respectively) compared with the normal BMI group. BMI cutoff value was 20.44 kg/m(2). Adding the BMI cutoff value to cancer staging could increase discriminatory performance in terms of integrated area under the curve and Harrell’s concordance index. CONCLUSION: Compared to normal BMI, underweight BMI was associated with poor survival whereas obese BMI was associated with better survival. BMI cutoff value of 20.44 kg/m(2) is a useful discriminator in Asian patients with CRC. Korean Cancer Association 2022-07 2021-10-15 /pmc/articles/PMC9296949/ /pubmed/34665954 http://dx.doi.org/10.4143/crt.2021.656 Text en Copyright © 2022 by the Korean Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Sangwon Lee, Dong Hee Lee, Jae-Hoon Shin, Su-Jin Lee, Hye Sun Park, Eun Jung Baik, Seung Hyuk Lee, Kang Young Kang, Jeonghyun Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer |
title | Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer |
title_full | Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer |
title_fullStr | Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer |
title_full_unstemmed | Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer |
title_short | Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer |
title_sort | association of body mass index with survival in asian patients with colorectal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296949/ https://www.ncbi.nlm.nih.gov/pubmed/34665954 http://dx.doi.org/10.4143/crt.2021.656 |
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