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Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids

Histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through the deacetylation of nuclear histone and non-histone proteins and are promising therapeutic targets for the treatment of various diseases. Here, the synthesis of new compounds in which a hydroxamic...

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Detalles Bibliográficos
Autores principales:	Jakubkiene, Virginija, Valiulis, Gabrielius Ernis, Schweipert, Markus, Zubriene, Asta, Matulis, Daumantas, Meyer-Almes, Franz-Josef, Tumkevicius, Sigitas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2022
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296983/ https://www.ncbi.nlm.nih.gov/pubmed/35923158 http://dx.doi.org/10.3762/bjoc.18.84

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