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A case of adrenal insufficiency during multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a disease related to coronavirus disease 2019 (COVID-19). Although the effects of COVID-19 on many systems are known, there is limited data regarding its effects on the endocrine system. This study aimed to discuss the effect of COVID-19 on co...

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Autores principales: Kilci, Fatih, Yetimakman, Ayşe Filiz, Jones, Jeremy Huw, Çizmecioğlu, Filiz Mine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Pediatric Endocrinology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297178/
https://www.ncbi.nlm.nih.gov/pubmed/35928381
http://dx.doi.org/10.1297/cpe.2022-0011
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author Kilci, Fatih
Yetimakman, Ayşe Filiz
Jones, Jeremy Huw
Çizmecioğlu, Filiz Mine
author_facet Kilci, Fatih
Yetimakman, Ayşe Filiz
Jones, Jeremy Huw
Çizmecioğlu, Filiz Mine
author_sort Kilci, Fatih
collection PubMed
description Multisystem inflammatory syndrome in children (MIS-C) is a disease related to coronavirus disease 2019 (COVID-19). Although the effects of COVID-19 on many systems are known, there is limited data regarding its effects on the endocrine system. This study aimed to discuss the effect of COVID-19 on cortisol dynamics in a patient who developed adrenal insufficiency after COVID-19 infection. An 11-yr-old boy with polymerase chain reaction-proven COVID-19 one month previously was referred with a five-day history of fever, vomiting, and rash. On admission, he had hypotension, tachycardia, and severe hyponatremia. After the evaluation, he was diagnosed with MIS-C and glucocorticoid therapy was initiated. During follow-up, the patient experienced adrenal insufficiency, and hydrocortisone treatment was initiated at a crisis dose. Four months later, the adrenal axis function had not recovered. The adrenocortical response in COVID-19 patients may be significantly impaired, resulting in increased mortality or morbidity.
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spelling pubmed-92971782022-08-03 A case of adrenal insufficiency during multisystem inflammatory syndrome in children Kilci, Fatih Yetimakman, Ayşe Filiz Jones, Jeremy Huw Çizmecioğlu, Filiz Mine Clin Pediatr Endocrinol Case Report Multisystem inflammatory syndrome in children (MIS-C) is a disease related to coronavirus disease 2019 (COVID-19). Although the effects of COVID-19 on many systems are known, there is limited data regarding its effects on the endocrine system. This study aimed to discuss the effect of COVID-19 on cortisol dynamics in a patient who developed adrenal insufficiency after COVID-19 infection. An 11-yr-old boy with polymerase chain reaction-proven COVID-19 one month previously was referred with a five-day history of fever, vomiting, and rash. On admission, he had hypotension, tachycardia, and severe hyponatremia. After the evaluation, he was diagnosed with MIS-C and glucocorticoid therapy was initiated. During follow-up, the patient experienced adrenal insufficiency, and hydrocortisone treatment was initiated at a crisis dose. Four months later, the adrenal axis function had not recovered. The adrenocortical response in COVID-19 patients may be significantly impaired, resulting in increased mortality or morbidity. The Japanese Society for Pediatric Endocrinology 2022-03-30 2022 /pmc/articles/PMC9297178/ /pubmed/35928381 http://dx.doi.org/10.1297/cpe.2022-0011 Text en 2022©The Japanese Society for Pediatric Endocrinology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Case Report
Kilci, Fatih
Yetimakman, Ayşe Filiz
Jones, Jeremy Huw
Çizmecioğlu, Filiz Mine
A case of adrenal insufficiency during multisystem inflammatory syndrome in children
title A case of adrenal insufficiency during multisystem inflammatory syndrome in children
title_full A case of adrenal insufficiency during multisystem inflammatory syndrome in children
title_fullStr A case of adrenal insufficiency during multisystem inflammatory syndrome in children
title_full_unstemmed A case of adrenal insufficiency during multisystem inflammatory syndrome in children
title_short A case of adrenal insufficiency during multisystem inflammatory syndrome in children
title_sort case of adrenal insufficiency during multisystem inflammatory syndrome in children
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297178/
https://www.ncbi.nlm.nih.gov/pubmed/35928381
http://dx.doi.org/10.1297/cpe.2022-0011
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