Gut Barrier in Critical States of the Body

The intestinal barrier (IB) is a system of diffusion barriers separating the intestinal chyme and blood. The aim of the review is to identify the role of IB dysfunction in the formation of critical states of the body and to substantiate ways to prevent these states. Toxic substances produced by norm...

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Autores principales: Schäfer, T. V., Vakunenkova, O. A., Ivnitsky, Ju. Ju., Golovko, A. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297268/
http://dx.doi.org/10.1134/S2079086422040077
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author Schäfer, T. V.
Vakunenkova, O. A.
Ivnitsky, Ju. Ju.
Golovko, A. I.
author_facet Schäfer, T. V.
Vakunenkova, O. A.
Ivnitsky, Ju. Ju.
Golovko, A. I.
author_sort Schäfer, T. V.
collection PubMed
description The intestinal barrier (IB) is a system of diffusion barriers separating the intestinal chyme and blood. The aim of the review is to identify the role of IB dysfunction in the formation of critical states of the body and to substantiate ways to prevent these states. Toxic substances produced by normal intestinal microflora are characterized. The involvement of endotoxin and ammonia in the pathogenesis of sepsis, acute circulatory disorders, secondary acute pulmonary lesions, and acute cerebral insufficiency is shown. Approaches to protect the IB in critical states of the body are proposed.
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spelling pubmed-92972682022-07-20 Gut Barrier in Critical States of the Body Schäfer, T. V. Vakunenkova, O. A. Ivnitsky, Ju. Ju. Golovko, A. I. Biol Bull Rev Article The intestinal barrier (IB) is a system of diffusion barriers separating the intestinal chyme and blood. The aim of the review is to identify the role of IB dysfunction in the formation of critical states of the body and to substantiate ways to prevent these states. Toxic substances produced by normal intestinal microflora are characterized. The involvement of endotoxin and ammonia in the pathogenesis of sepsis, acute circulatory disorders, secondary acute pulmonary lesions, and acute cerebral insufficiency is shown. Approaches to protect the IB in critical states of the body are proposed. Pleiades Publishing 2022-07-20 2022 /pmc/articles/PMC9297268/ http://dx.doi.org/10.1134/S2079086422040077 Text en © Pleiades Publishing, Ltd. 2022, ISSN 2079-0864, Biology Bulletin Reviews, 2022, Vol. 12, No. 4, pp. 392–405. © Pleiades Publishing, Ltd., 2022.Russian Text © The Author(s), 2022, published in Uspekhi Sovremennoi Biologii, 2022, Vol. 142, No. 2, pp. 138–152. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Schäfer, T. V.
Vakunenkova, O. A.
Ivnitsky, Ju. Ju.
Golovko, A. I.
Gut Barrier in Critical States of the Body
title Gut Barrier in Critical States of the Body
title_full Gut Barrier in Critical States of the Body
title_fullStr Gut Barrier in Critical States of the Body
title_full_unstemmed Gut Barrier in Critical States of the Body
title_short Gut Barrier in Critical States of the Body
title_sort gut barrier in critical states of the body
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297268/
http://dx.doi.org/10.1134/S2079086422040077
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