Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease

The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early infection compared with the standard 2-tier algorithm while retaining high specificity in a region with a...

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Detalles Bibliográficos
Autores principales: Khan, Farhan, Allehebi, Ziyad, Shabi, Yahya, Davis, Ian, LeBlanc, Jason, Lindsay, Robbin, Hatchette, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297310/
https://www.ncbi.nlm.nih.gov/pubmed/35873285
http://dx.doi.org/10.1093/ofid/ofac272
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author Khan, Farhan
Allehebi, Ziyad
Shabi, Yahya
Davis, Ian
LeBlanc, Jason
Lindsay, Robbin
Hatchette, Todd
author_facet Khan, Farhan
Allehebi, Ziyad
Shabi, Yahya
Davis, Ian
LeBlanc, Jason
Lindsay, Robbin
Hatchette, Todd
author_sort Khan, Farhan
collection PubMed
description The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early infection compared with the standard 2-tier algorithm while retaining high specificity in a region with a high incidence of LD.
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spelling pubmed-92973102022-07-21 Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease Khan, Farhan Allehebi, Ziyad Shabi, Yahya Davis, Ian LeBlanc, Jason Lindsay, Robbin Hatchette, Todd Open Forum Infect Dis Brief Report The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early infection compared with the standard 2-tier algorithm while retaining high specificity in a region with a high incidence of LD. Oxford University Press 2022-06-06 /pmc/articles/PMC9297310/ /pubmed/35873285 http://dx.doi.org/10.1093/ofid/ofac272 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Khan, Farhan
Allehebi, Ziyad
Shabi, Yahya
Davis, Ian
LeBlanc, Jason
Lindsay, Robbin
Hatchette, Todd
Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
title Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
title_full Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
title_fullStr Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
title_full_unstemmed Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
title_short Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
title_sort modified two-tiered testing enzyme immunoassay algorithm for serologic diagnosis of lyme disease
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297310/
https://www.ncbi.nlm.nih.gov/pubmed/35873285
http://dx.doi.org/10.1093/ofid/ofac272
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