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Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows

BACKGROUND: This study was conducted to detect potential polymorphisms of the serum amyloid A2 (SAA2) gene and explore their relationships with milk production traits in Chinese Holstein cows. OBJECTIVES: THIS STUDY USED: sequencing technology conducted in 532 Chinese Holstein cows. METHODS: Three s...

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Autores principales: Raza, Sayed Haidar Abbas, Liang, Chengcheng, Alshammari, Ahmed Mohajja, Aloufi, Bandar H., Gui, Linsheng, Khan, Rajwali, Zan, Linsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297766/
https://www.ncbi.nlm.nih.gov/pubmed/35470977
http://dx.doi.org/10.1002/vms3.796
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author Raza, Sayed Haidar Abbas
Liang, Chengcheng
Alshammari, Ahmed Mohajja
Aloufi, Bandar H.
Gui, Linsheng
Khan, Rajwali
Zan, Linsen
author_facet Raza, Sayed Haidar Abbas
Liang, Chengcheng
Alshammari, Ahmed Mohajja
Aloufi, Bandar H.
Gui, Linsheng
Khan, Rajwali
Zan, Linsen
author_sort Raza, Sayed Haidar Abbas
collection PubMed
description BACKGROUND: This study was conducted to detect potential polymorphisms of the serum amyloid A2 (SAA2) gene and explore their relationships with milk production traits in Chinese Holstein cows. OBJECTIVES: THIS STUDY USED: sequencing technology conducted in 532 Chinese Holstein cows. METHODS: Three single nucleotide polymorphisms (SNPs) were identified within intron 1, named g.14061A>G, g.14072G>C and g.14819C>T. Eight estimated haplotypes were identified, of which three major haplotypes had a frequency of Hap3 (‐ACC‐), Hap5 (‐GCC‐) and Hap2 (‐AGT‐), with 17.9%, 12.30% and 8.10%, respectively. RESULTS: The association analysis of single markers (g.14061A>G and g.14819C>T) and combined genotypes (Hap1/5) revealed prominent effects on milk production traits in Chinese Holstein cows (p < 0.05). CONCLUSIONS: Our results suggest that the SAA2 gene is associated with economic traits in Chinese Holstein cows and may be used as candidate gene for marker‐assisted selection and management in breeding programs.
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spelling pubmed-92977662022-07-22 Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows Raza, Sayed Haidar Abbas Liang, Chengcheng Alshammari, Ahmed Mohajja Aloufi, Bandar H. Gui, Linsheng Khan, Rajwali Zan, Linsen Vet Med Sci OTHER BACKGROUND: This study was conducted to detect potential polymorphisms of the serum amyloid A2 (SAA2) gene and explore their relationships with milk production traits in Chinese Holstein cows. OBJECTIVES: THIS STUDY USED: sequencing technology conducted in 532 Chinese Holstein cows. METHODS: Three single nucleotide polymorphisms (SNPs) were identified within intron 1, named g.14061A>G, g.14072G>C and g.14819C>T. Eight estimated haplotypes were identified, of which three major haplotypes had a frequency of Hap3 (‐ACC‐), Hap5 (‐GCC‐) and Hap2 (‐AGT‐), with 17.9%, 12.30% and 8.10%, respectively. RESULTS: The association analysis of single markers (g.14061A>G and g.14819C>T) and combined genotypes (Hap1/5) revealed prominent effects on milk production traits in Chinese Holstein cows (p < 0.05). CONCLUSIONS: Our results suggest that the SAA2 gene is associated with economic traits in Chinese Holstein cows and may be used as candidate gene for marker‐assisted selection and management in breeding programs. John Wiley and Sons Inc. 2022-04-26 /pmc/articles/PMC9297766/ /pubmed/35470977 http://dx.doi.org/10.1002/vms3.796 Text en © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle OTHER
Raza, Sayed Haidar Abbas
Liang, Chengcheng
Alshammari, Ahmed Mohajja
Aloufi, Bandar H.
Gui, Linsheng
Khan, Rajwali
Zan, Linsen
Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows
title Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows
title_full Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows
title_fullStr Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows
title_full_unstemmed Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows
title_short Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows
title_sort genetic variants in the serum amyloid a2 (saa2) gene as a potential marker for milk production traits in chinese holstein cows
topic OTHER
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297766/
https://www.ncbi.nlm.nih.gov/pubmed/35470977
http://dx.doi.org/10.1002/vms3.796
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