RNase H-based analysis of synthetic mRNA 5′ cap incorporation

Advances in mRNA synthesis and lipid nanoparticles technologies have helped make mRNA therapeutics and vaccines a reality. The 5′ cap structure is a crucial modification required to functionalize synthetic mRNA for efficient protein translation in vivo and evasion of cellular innate immune responses...

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Detalles Bibliográficos
Autores principales: Chan, S. Hong, Whipple, Joseph M., Dai, Nan, Kelley, Theresa M., Withers, Kathryn, Tzertzinis, George, Corrêa, Ivan R., Robb, G. Brett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297845/
https://www.ncbi.nlm.nih.gov/pubmed/35680168
http://dx.doi.org/10.1261/rna.079173.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297845/
https://www.ncbi.nlm.nih.gov/pubmed/35680168
http://dx.doi.org/10.1261/rna.079173.122

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