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Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera

Recapping of Varroa destructor‐infested brood cells is a trait that has recently attracted interest in honey bee breeding to select mite‐resistant Apis mellifera colonies. To investigate the genetic architecture of this trait, we evaluated a sample of A. mellifera mellifera colonies (N = 155) from S...

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Autores principales: Guichard, M., Dainat, B., Eynard, S., Vignal, A., Servin, B., Neuditschko, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297925/
https://www.ncbi.nlm.nih.gov/pubmed/34729804
http://dx.doi.org/10.1111/age.13150
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author Guichard, M.
Dainat, B.
Eynard, S.
Vignal, A.
Servin, B.
Neuditschko, M.
author_facet Guichard, M.
Dainat, B.
Eynard, S.
Vignal, A.
Servin, B.
Neuditschko, M.
author_sort Guichard, M.
collection PubMed
description Recapping of Varroa destructor‐infested brood cells is a trait that has recently attracted interest in honey bee breeding to select mite‐resistant Apis mellifera colonies. To investigate the genetic architecture of this trait, we evaluated a sample of A. mellifera mellifera colonies (N = 155) from Switzerland and France and performed a genome‐wide association study, using a pool of 500 workers per colony for next‐generation sequencing. The results revealed that two QTL were significantly (P < 0.05) associated with recapping of V. destructor‐infested brood cells. The best‐associated QTL is located on chromosome 5 in a region previously found to be associated with grooming behaviour, a resistance trait against V. destructor, in A. mellifera and Apis cerana. The second best‐associated QTL is located on chromosome 4 in an intron of the Dscam gene, which is involved in neuronal wiring. Previous research demonstrated that genes involved in neuronal wiring are associated with recapping and varroa sensitive hygiene. Therefore, our study confirms the role of a gene region on chromosome 5 in social immunity and simultaneously provides novel insights into genetic interactions between common mite resistance traits in honey bees.
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spelling pubmed-92979252022-07-21 Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera Guichard, M. Dainat, B. Eynard, S. Vignal, A. Servin, B. Neuditschko, M. Anim Genet Short Communications Recapping of Varroa destructor‐infested brood cells is a trait that has recently attracted interest in honey bee breeding to select mite‐resistant Apis mellifera colonies. To investigate the genetic architecture of this trait, we evaluated a sample of A. mellifera mellifera colonies (N = 155) from Switzerland and France and performed a genome‐wide association study, using a pool of 500 workers per colony for next‐generation sequencing. The results revealed that two QTL were significantly (P < 0.05) associated with recapping of V. destructor‐infested brood cells. The best‐associated QTL is located on chromosome 5 in a region previously found to be associated with grooming behaviour, a resistance trait against V. destructor, in A. mellifera and Apis cerana. The second best‐associated QTL is located on chromosome 4 in an intron of the Dscam gene, which is involved in neuronal wiring. Previous research demonstrated that genes involved in neuronal wiring are associated with recapping and varroa sensitive hygiene. Therefore, our study confirms the role of a gene region on chromosome 5 in social immunity and simultaneously provides novel insights into genetic interactions between common mite resistance traits in honey bees. John Wiley and Sons Inc. 2021-11-02 2022-02 /pmc/articles/PMC9297925/ /pubmed/34729804 http://dx.doi.org/10.1111/age.13150 Text en © 2021 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Short Communications
Guichard, M.
Dainat, B.
Eynard, S.
Vignal, A.
Servin, B.
Neuditschko, M.
Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera
title Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera
title_full Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera
title_fullStr Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera
title_full_unstemmed Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera
title_short Two quantitative trait loci are associated with recapping of Varroa destructor‐infested brood cells in Apis mellifera mellifera
title_sort two quantitative trait loci are associated with recapping of varroa destructor‐infested brood cells in apis mellifera mellifera
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297925/
https://www.ncbi.nlm.nih.gov/pubmed/34729804
http://dx.doi.org/10.1111/age.13150
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