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Chemical and Enzymatic Synthesis of Sialylated Glycoforms of Human Erythropoietin

Recombinant human erythropoietin (EPO) is the main therapeutic glycoprotein for the treatment of anemia in cancer and kidney patients. The in‐vivo activity of EPO is carbohydrate‐dependent with the number of sialic acid residues regulating its circulatory half‐life. EPO carries three N‐glycans and t...

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Detalles Bibliográficos
Autores principales:	Hessefort, Hendrik, Gross, Angelina, Seeleithner, Simone, Hessefort, Markus, Kirsch, Tanja, Perkams, Lukas, Bundgaard, Klaus Ole, Gottwald, Karen, Rau, David, Graf, Christopher Günther Franz, Rozanski, Elisabeth, Weidler, Sascha, Unverzagt, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297946/ https://www.ncbi.nlm.nih.gov/pubmed/34523784 http://dx.doi.org/10.1002/anie.202110013

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