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Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites

Primary cutaneous anaplastic large‐cell lymphoma (pC‐ALCL) is distinguished from systemic anaplastic large‐cell lymphoma (S‐ALCL) with cutaneous involvement. Although pC‐ALCL is a unique entity with different genetics, clinical characteristics, and prognosis, its causes are unknown. Herein, we repor...

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Autores principales: Zhang, Yaping, Chen, Min, Yu, Yu, Liu, Xiaoyu, Liu, Weiping, Jiang, Lijun, Zhang, Wenyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297975/
https://www.ncbi.nlm.nih.gov/pubmed/34622970
http://dx.doi.org/10.1111/cup.14147
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author Zhang, Yaping
Chen, Min
Yu, Yu
Liu, Xiaoyu
Liu, Weiping
Jiang, Lijun
Zhang, Wenyan
author_facet Zhang, Yaping
Chen, Min
Yu, Yu
Liu, Xiaoyu
Liu, Weiping
Jiang, Lijun
Zhang, Wenyan
author_sort Zhang, Yaping
collection PubMed
description Primary cutaneous anaplastic large‐cell lymphoma (pC‐ALCL) is distinguished from systemic anaplastic large‐cell lymphoma (S‐ALCL) with cutaneous involvement. Although pC‐ALCL is a unique entity with different genetics, clinical characteristics, and prognosis, its causes are unknown. Herein, we report the case of a Chinese woman with a 4‐month history of a gradually enlarged ulcerative mass in her right forearm following an unidentified insect bite. Biopsy revealed an extensive infiltrate with patches of large anaplastic lymphoid cells. These cells were immunohistochemically positive for CD45, CD30, and TIA‐1 and negative for CD2, CD3, CD4, CD5, CD20, CD7, CD8, and ALK‐1. DUSP22‐IRF4 rearrangement was detected; on the other hand, TP63 rearrangement was not observed by fluorescence in situ hybridization (FISH). No Epstein‐Barr virus‐encoded small RNAs (EBERs) were detected by ISH. Rearrangement of monoclonal TCR gene was found using BIOMED‐2 polymerase chain reaction. No abnormality was found on the subsequent positron emission tomography‐computed tomography (PET‐CT) scan. After five cycles of cyclophosphamide + doxorubicin + vincristine + prednisolone (CHOP) chemotherapy, the patient achieved complete remission. This is the first report of a unique pC‐ALCL with DUSP22‐IRF4 rearrangement following an insect bite other than S‐ALCL involving the skin.
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spelling pubmed-92979752022-07-21 Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites Zhang, Yaping Chen, Min Yu, Yu Liu, Xiaoyu Liu, Weiping Jiang, Lijun Zhang, Wenyan J Cutan Pathol Case Reports Primary cutaneous anaplastic large‐cell lymphoma (pC‐ALCL) is distinguished from systemic anaplastic large‐cell lymphoma (S‐ALCL) with cutaneous involvement. Although pC‐ALCL is a unique entity with different genetics, clinical characteristics, and prognosis, its causes are unknown. Herein, we report the case of a Chinese woman with a 4‐month history of a gradually enlarged ulcerative mass in her right forearm following an unidentified insect bite. Biopsy revealed an extensive infiltrate with patches of large anaplastic lymphoid cells. These cells were immunohistochemically positive for CD45, CD30, and TIA‐1 and negative for CD2, CD3, CD4, CD5, CD20, CD7, CD8, and ALK‐1. DUSP22‐IRF4 rearrangement was detected; on the other hand, TP63 rearrangement was not observed by fluorescence in situ hybridization (FISH). No Epstein‐Barr virus‐encoded small RNAs (EBERs) were detected by ISH. Rearrangement of monoclonal TCR gene was found using BIOMED‐2 polymerase chain reaction. No abnormality was found on the subsequent positron emission tomography‐computed tomography (PET‐CT) scan. After five cycles of cyclophosphamide + doxorubicin + vincristine + prednisolone (CHOP) chemotherapy, the patient achieved complete remission. This is the first report of a unique pC‐ALCL with DUSP22‐IRF4 rearrangement following an insect bite other than S‐ALCL involving the skin. Blackwell Publishing Ltd. 2021-10-20 2022-02 /pmc/articles/PMC9297975/ /pubmed/34622970 http://dx.doi.org/10.1111/cup.14147 Text en © 2021 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Zhang, Yaping
Chen, Min
Yu, Yu
Liu, Xiaoyu
Liu, Weiping
Jiang, Lijun
Zhang, Wenyan
Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites
title Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites
title_full Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites
title_fullStr Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites
title_full_unstemmed Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites
title_short Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites
title_sort primary cutaneous anaplastic large‐cell lymphoma with dusp22‐irf4 rearrangement following insect bites
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297975/
https://www.ncbi.nlm.nih.gov/pubmed/34622970
http://dx.doi.org/10.1111/cup.14147
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