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The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet

OBJECTIVE: The study aimed to determine the effect of Acalypha indica Linn. (AI) root extract and a combination of simvastatin–AI on improving the fatty pancreas in Sprague–Dawley rats induced with a high fructose and cholesterol diet. MATERIALS AND METHODS: Twenty-four male Sprague–Dawley rats were...

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Autores principales: Krisnamurti, Desak Gede Budi, Farida, Siti, Putri, Rizky Clarinta, Fachri, Wilzar, Purwaningsih, Erni Hernawati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A periodical of the Network for the Veterinarians of Bangladesh (BDvetNET) 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298090/
https://www.ncbi.nlm.nih.gov/pubmed/35891667
http://dx.doi.org/10.5455/javar.2022.i601
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author Krisnamurti, Desak Gede Budi
Farida, Siti
Putri, Rizky Clarinta
Fachri, Wilzar
Purwaningsih, Erni Hernawati
author_facet Krisnamurti, Desak Gede Budi
Farida, Siti
Putri, Rizky Clarinta
Fachri, Wilzar
Purwaningsih, Erni Hernawati
author_sort Krisnamurti, Desak Gede Budi
collection PubMed
description OBJECTIVE: The study aimed to determine the effect of Acalypha indica Linn. (AI) root extract and a combination of simvastatin–AI on improving the fatty pancreas in Sprague–Dawley rats induced with a high fructose and cholesterol diet. MATERIALS AND METHODS: Twenty-four male Sprague–Dawley rats were induced with a high fructose and cholesterol diet for 4 weeks before being divided into four groups. Each group receiving treatments consisting of simvastatin only, A. indica extracts only, or simvastatin–A. indica extract combination. A histological examination was conducted to determine the effect of each treatment. Also, one-way analysis of variance (ANOVA) and post-hoc Bonferroni test were conducted to assess the comparison of groups from the histological examination. RESULTS: Significant improvement was found in fatty pancreas between rats without therapy and rats treated with simvastatin therapy (p = 0.024, 95% CI: 0.038–0.696), and also between rats without treatment and rats treated with simvastatin–A. indica extract combination therapy (p = 0.000, 95% CI: 0.241–0.873) using one-way ANOVA and the post-hoc Bonferroni test. CONCLUSIONS: The results of the combination of simvastatin–A. indica Linn. root extracts treatment showed a synergistic effect on the improvement of fatty pancreas, but further research is needed to find potential adverse effects on the interaction of these two substrates to confirm the safe use of this treatment.
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spelling pubmed-92980902022-07-25 The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet Krisnamurti, Desak Gede Budi Farida, Siti Putri, Rizky Clarinta Fachri, Wilzar Purwaningsih, Erni Hernawati J Adv Vet Anim Res Short Communication OBJECTIVE: The study aimed to determine the effect of Acalypha indica Linn. (AI) root extract and a combination of simvastatin–AI on improving the fatty pancreas in Sprague–Dawley rats induced with a high fructose and cholesterol diet. MATERIALS AND METHODS: Twenty-four male Sprague–Dawley rats were induced with a high fructose and cholesterol diet for 4 weeks before being divided into four groups. Each group receiving treatments consisting of simvastatin only, A. indica extracts only, or simvastatin–A. indica extract combination. A histological examination was conducted to determine the effect of each treatment. Also, one-way analysis of variance (ANOVA) and post-hoc Bonferroni test were conducted to assess the comparison of groups from the histological examination. RESULTS: Significant improvement was found in fatty pancreas between rats without therapy and rats treated with simvastatin therapy (p = 0.024, 95% CI: 0.038–0.696), and also between rats without treatment and rats treated with simvastatin–A. indica extract combination therapy (p = 0.000, 95% CI: 0.241–0.873) using one-way ANOVA and the post-hoc Bonferroni test. CONCLUSIONS: The results of the combination of simvastatin–A. indica Linn. root extracts treatment showed a synergistic effect on the improvement of fatty pancreas, but further research is needed to find potential adverse effects on the interaction of these two substrates to confirm the safe use of this treatment. A periodical of the Network for the Veterinarians of Bangladesh (BDvetNET) 2022-06-30 /pmc/articles/PMC9298090/ /pubmed/35891667 http://dx.doi.org/10.5455/javar.2022.i601 Text en Copyright: © Journal of Advanced Veterinary and Animal Research https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) )
spellingShingle Short Communication
Krisnamurti, Desak Gede Budi
Farida, Siti
Putri, Rizky Clarinta
Fachri, Wilzar
Purwaningsih, Erni Hernawati
The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
title The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
title_full The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
title_fullStr The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
title_full_unstemmed The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
title_short The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
title_sort effect of simvastatin–acalypha indica linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298090/
https://www.ncbi.nlm.nih.gov/pubmed/35891667
http://dx.doi.org/10.5455/javar.2022.i601
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