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Dynamic causal modelling of COVID-19 and its mitigations

This technical report describes the dynamic causal modelling of mitigated epidemiological outcomes during the COVID-9 coronavirus outbreak in 2020. Dynamic causal modelling is a form of complex system modelling, which uses ‘real world’ timeseries to estimate the parameters of an underlying state spa...

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Autores principales: Friston, Karl J., Flandin, Guillaume, Razi, Adeel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298167/
https://www.ncbi.nlm.nih.gov/pubmed/35859054
http://dx.doi.org/10.1038/s41598-022-16799-8
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author Friston, Karl J.
Flandin, Guillaume
Razi, Adeel
author_facet Friston, Karl J.
Flandin, Guillaume
Razi, Adeel
author_sort Friston, Karl J.
collection PubMed
description This technical report describes the dynamic causal modelling of mitigated epidemiological outcomes during the COVID-9 coronavirus outbreak in 2020. Dynamic causal modelling is a form of complex system modelling, which uses ‘real world’ timeseries to estimate the parameters of an underlying state space model using variational Bayesian procedures. Its key contribution—in an epidemiological setting—is to embed conventional models within a larger model of sociobehavioural responses—in a way that allows for (relatively assumption-free) forecasting. One advantage of using variational Bayes is that one can progressively optimise the model via Bayesian model selection: generally, the most likely models become more expressive as more data becomes available. This report summarises the model (on 6-Nov-20), eight months after the inception of dynamic causal modelling for COVID-19. This model—and its subsequent updates—is used to provide nowcasts and forecasts of latent behavioural and epidemiological variables as an open science resource. The current report describes the underlying model structure and the rationale for the variational procedures that underwrite Bayesian model selection.
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spelling pubmed-92981672022-07-21 Dynamic causal modelling of COVID-19 and its mitigations Friston, Karl J. Flandin, Guillaume Razi, Adeel Sci Rep Article This technical report describes the dynamic causal modelling of mitigated epidemiological outcomes during the COVID-9 coronavirus outbreak in 2020. Dynamic causal modelling is a form of complex system modelling, which uses ‘real world’ timeseries to estimate the parameters of an underlying state space model using variational Bayesian procedures. Its key contribution—in an epidemiological setting—is to embed conventional models within a larger model of sociobehavioural responses—in a way that allows for (relatively assumption-free) forecasting. One advantage of using variational Bayes is that one can progressively optimise the model via Bayesian model selection: generally, the most likely models become more expressive as more data becomes available. This report summarises the model (on 6-Nov-20), eight months after the inception of dynamic causal modelling for COVID-19. This model—and its subsequent updates—is used to provide nowcasts and forecasts of latent behavioural and epidemiological variables as an open science resource. The current report describes the underlying model structure and the rationale for the variational procedures that underwrite Bayesian model selection. Nature Publishing Group UK 2022-07-20 /pmc/articles/PMC9298167/ /pubmed/35859054 http://dx.doi.org/10.1038/s41598-022-16799-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Friston, Karl J.
Flandin, Guillaume
Razi, Adeel
Dynamic causal modelling of COVID-19 and its mitigations
title Dynamic causal modelling of COVID-19 and its mitigations
title_full Dynamic causal modelling of COVID-19 and its mitigations
title_fullStr Dynamic causal modelling of COVID-19 and its mitigations
title_full_unstemmed Dynamic causal modelling of COVID-19 and its mitigations
title_short Dynamic causal modelling of COVID-19 and its mitigations
title_sort dynamic causal modelling of covid-19 and its mitigations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298167/
https://www.ncbi.nlm.nih.gov/pubmed/35859054
http://dx.doi.org/10.1038/s41598-022-16799-8
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