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Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo

SARS-CoV-2 infection involves the phase of viral replication and inflammatory response predicting the severity of COVID-19. The aim of the study was to analyze the association between IL-6 and hematological and inflammatory parameters and outcomes of patients with COVID-19. Plasma interleukin 6 (IL-...

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Autores principales: Latifi-Pupovci, Hatixhe, Namani, Sadie, Ahmetaj-Shala, Blerina, Pajaziti, Artina, Bunjaku, Gramoz, Ajazaj Berisha, Lindita, Gegaj, Valentin, Kotori, Afrim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298187/
https://www.ncbi.nlm.nih.gov/pubmed/35873360
http://dx.doi.org/10.1155/2022/4461647
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author Latifi-Pupovci, Hatixhe
Namani, Sadie
Ahmetaj-Shala, Blerina
Pajaziti, Artina
Bunjaku, Gramoz
Ajazaj Berisha, Lindita
Gegaj, Valentin
Kotori, Afrim
author_facet Latifi-Pupovci, Hatixhe
Namani, Sadie
Ahmetaj-Shala, Blerina
Pajaziti, Artina
Bunjaku, Gramoz
Ajazaj Berisha, Lindita
Gegaj, Valentin
Kotori, Afrim
author_sort Latifi-Pupovci, Hatixhe
collection PubMed
description SARS-CoV-2 infection involves the phase of viral replication and inflammatory response predicting the severity of COVID-19. The aim of the study was to analyze the association between IL-6 and hematological and inflammatory parameters and outcomes of patients with COVID-19. Plasma interleukin 6 (IL-6) levels and other inflammatory and hematological parameters were analyzed in 86 adult patients diagnosed with SARS-CoV-2 infection in Kosovo. The median age of patients was 61.50 (49.75–67.25) years. Over half of patients were categorised as severe (58%) and had comorbidities (69%) with hypertension being the most common. The overall mortality rate was 4.7%. The distribution of biochemical parameters across disease severity groups was significantly different for C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and granulocytes with higher median values in more severe and critically ill patients whereas lower percentage of lymphocytes, monocytes, and platelet count in severe and critically ill patients. IL-6 levels were increased in 63% of patients with significant differences in the distribution across the following groups; age, disease severity, hospitalisation status, pulmonary infiltrates, oxygen therapy, and hypertension status. IL-6 significantly correlated with CRP, LDH, CK, ESR, and percentages of granulocytes. IL-6 and other inflammatory and hematological parameters were strongly associated with disease severity and may predict the outcome of the SARS-CoV-2 infection.
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spelling pubmed-92981872022-07-21 Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo Latifi-Pupovci, Hatixhe Namani, Sadie Ahmetaj-Shala, Blerina Pajaziti, Artina Bunjaku, Gramoz Ajazaj Berisha, Lindita Gegaj, Valentin Kotori, Afrim Can J Infect Dis Med Microbiol Research Article SARS-CoV-2 infection involves the phase of viral replication and inflammatory response predicting the severity of COVID-19. The aim of the study was to analyze the association between IL-6 and hematological and inflammatory parameters and outcomes of patients with COVID-19. Plasma interleukin 6 (IL-6) levels and other inflammatory and hematological parameters were analyzed in 86 adult patients diagnosed with SARS-CoV-2 infection in Kosovo. The median age of patients was 61.50 (49.75–67.25) years. Over half of patients were categorised as severe (58%) and had comorbidities (69%) with hypertension being the most common. The overall mortality rate was 4.7%. The distribution of biochemical parameters across disease severity groups was significantly different for C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and granulocytes with higher median values in more severe and critically ill patients whereas lower percentage of lymphocytes, monocytes, and platelet count in severe and critically ill patients. IL-6 levels were increased in 63% of patients with significant differences in the distribution across the following groups; age, disease severity, hospitalisation status, pulmonary infiltrates, oxygen therapy, and hypertension status. IL-6 significantly correlated with CRP, LDH, CK, ESR, and percentages of granulocytes. IL-6 and other inflammatory and hematological parameters were strongly associated with disease severity and may predict the outcome of the SARS-CoV-2 infection. Hindawi 2022-07-15 /pmc/articles/PMC9298187/ /pubmed/35873360 http://dx.doi.org/10.1155/2022/4461647 Text en Copyright © 2022 Hatixhe Latifi-Pupovci et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Latifi-Pupovci, Hatixhe
Namani, Sadie
Ahmetaj-Shala, Blerina
Pajaziti, Artina
Bunjaku, Gramoz
Ajazaj Berisha, Lindita
Gegaj, Valentin
Kotori, Afrim
Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo
title Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo
title_full Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo
title_fullStr Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo
title_full_unstemmed Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo
title_short Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo
title_sort biomarkers of inflammation among patients with covid-19: a single-centre prospective study from prishtina, kosovo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298187/
https://www.ncbi.nlm.nih.gov/pubmed/35873360
http://dx.doi.org/10.1155/2022/4461647
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