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Progress in the pathological arena of gynecological cancers
This review covers the significant new developments in the pathological classification of gynecological tumors. Many of these were included in the updated World Health Organization Classification of Female Genital Tract Tumours, published in 2020. Topics include the compelling evidence that a large...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298209/ https://www.ncbi.nlm.nih.gov/pubmed/34669206 http://dx.doi.org/10.1002/ijgo.13871 |
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author | McCluggage, W. Glenn |
author_facet | McCluggage, W. Glenn |
author_sort | McCluggage, W. Glenn |
collection | PubMed |
description | This review covers the significant new developments in the pathological classification of gynecological tumors. Many of these were included in the updated World Health Organization Classification of Female Genital Tract Tumours, published in 2020. Topics include the compelling evidence that a large majority of extrauterine high‐grade serous carcinomas arise from the fallopian tube; the Cancer Genome Atlas (TCGA) Classification of endometrial carcinomas; the discovery that most so‐called synchronous endometrial and ovarian endometrioid carcinomas represent metastasis from the endometrium to the ovary; and the division of cervical, vaginal, and vulval carcinomas into clinically meaningful HPV‐associated and HPV‐independent types. Newly described tumor types are covered, including endometrial and ovarian mesonephric‐like adenocarcinoma, uterine sarcoma types associated with specific molecular abnormalities, and gastric (gastrointestinal)‐type adenocarcinomas of the endometrium and vagina. Important molecular events in ovarian sex cord–stromal tumors are also discussed. |
format | Online Article Text |
id | pubmed-9298209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92982092022-07-21 Progress in the pathological arena of gynecological cancers McCluggage, W. Glenn Int J Gynaecol Obstet Chapters This review covers the significant new developments in the pathological classification of gynecological tumors. Many of these were included in the updated World Health Organization Classification of Female Genital Tract Tumours, published in 2020. Topics include the compelling evidence that a large majority of extrauterine high‐grade serous carcinomas arise from the fallopian tube; the Cancer Genome Atlas (TCGA) Classification of endometrial carcinomas; the discovery that most so‐called synchronous endometrial and ovarian endometrioid carcinomas represent metastasis from the endometrium to the ovary; and the division of cervical, vaginal, and vulval carcinomas into clinically meaningful HPV‐associated and HPV‐independent types. Newly described tumor types are covered, including endometrial and ovarian mesonephric‐like adenocarcinoma, uterine sarcoma types associated with specific molecular abnormalities, and gastric (gastrointestinal)‐type adenocarcinomas of the endometrium and vagina. Important molecular events in ovarian sex cord–stromal tumors are also discussed. John Wiley and Sons Inc. 2021-10-20 2021-10 /pmc/articles/PMC9298209/ /pubmed/34669206 http://dx.doi.org/10.1002/ijgo.13871 Text en © 2021 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chapters McCluggage, W. Glenn Progress in the pathological arena of gynecological cancers |
title | Progress in the pathological arena of gynecological cancers |
title_full | Progress in the pathological arena of gynecological cancers |
title_fullStr | Progress in the pathological arena of gynecological cancers |
title_full_unstemmed | Progress in the pathological arena of gynecological cancers |
title_short | Progress in the pathological arena of gynecological cancers |
title_sort | progress in the pathological arena of gynecological cancers |
topic | Chapters |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298209/ https://www.ncbi.nlm.nih.gov/pubmed/34669206 http://dx.doi.org/10.1002/ijgo.13871 |
work_keys_str_mv | AT mccluggagewglenn progressinthepathologicalarenaofgynecologicalcancers |