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Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya

BACKGROUND: HIV‐positive individuals who maintain an undetectable viral load cannot transmit the virus to others. In 2012, an HIV population‐based survey was conducted in Ndhiwa sub‐county (Kenya) to provide information on the HIV local epidemic. We carried out a second survey 6 years after the firs...

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Autores principales: Conan, Nolwenn, Badawi, Mahmoud, Chihana, Menard L., Wanjala, Stephen, Kingwara, Leonard, Mambula, Christopher, Ngugi, Catherine, Okomo, Gordon, Opollo, Valarie, Salumu, Leon, Nesbitt, Robin, Szumilin, Elisabeth, Huerga, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298256/
https://www.ncbi.nlm.nih.gov/pubmed/34637172
http://dx.doi.org/10.1111/tmi.13688
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author Conan, Nolwenn
Badawi, Mahmoud
Chihana, Menard L.
Wanjala, Stephen
Kingwara, Leonard
Mambula, Christopher
Ngugi, Catherine
Okomo, Gordon
Opollo, Valarie
Salumu, Leon
Nesbitt, Robin
Szumilin, Elisabeth
Huerga, Helena
author_facet Conan, Nolwenn
Badawi, Mahmoud
Chihana, Menard L.
Wanjala, Stephen
Kingwara, Leonard
Mambula, Christopher
Ngugi, Catherine
Okomo, Gordon
Opollo, Valarie
Salumu, Leon
Nesbitt, Robin
Szumilin, Elisabeth
Huerga, Helena
author_sort Conan, Nolwenn
collection PubMed
description BACKGROUND: HIV‐positive individuals who maintain an undetectable viral load cannot transmit the virus to others. In 2012, an HIV population‐based survey was conducted in Ndhiwa sub‐county (Kenya) to provide information on the HIV local epidemic. We carried out a second survey 6 years after the first one, to assess progress in HIV diagnosis and care and differences in the HIV prevalence and incidence between the two surveys. METHODS: A cross‐sectional, population‐based survey using cluster sampling and geospatial random selection was implemented in 2018, using the same design as 2012. Consenting participants aged 15–59 years were interviewed and tested for HIV at home. HIV‐positive individuals received viral load testing (viral suppression defined as <1000 copies/ml) and Lag‐Avidity EIA assay (to measure recent infection). The 90–90–90 UNAIDS indicators were also assessed. RESULTS: Overall, 6029 individuals were included in 2018. HIV prevalence was 16.9%. Viral suppression among all HIV‐positive was 88.3% in 2018 (vs. 39.9% in 2012, p < 0.001). HIV incidence was 0.75% in 2018 vs. 1.90% in 2012 (p = 0.07). In 2018, the 90–90–90 indicators were 93%–97%–95% (vs. 60%–68%–83% in 2012). CONCLUSION: A two‐fold increase in the HIV viral load suppression rate along with a decreasing trend in incidence was observed over 6 years in Ndhiwa sub‐county. Achieving high rates of viral suppression in HIV populations that can lead to reducing HIV transmission in sub‐Saharan contexts is feasible. Nevertheless, we will need further efforts to sustain this progress.
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spelling pubmed-92982562022-07-21 Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya Conan, Nolwenn Badawi, Mahmoud Chihana, Menard L. Wanjala, Stephen Kingwara, Leonard Mambula, Christopher Ngugi, Catherine Okomo, Gordon Opollo, Valarie Salumu, Leon Nesbitt, Robin Szumilin, Elisabeth Huerga, Helena Trop Med Int Health Research Articles BACKGROUND: HIV‐positive individuals who maintain an undetectable viral load cannot transmit the virus to others. In 2012, an HIV population‐based survey was conducted in Ndhiwa sub‐county (Kenya) to provide information on the HIV local epidemic. We carried out a second survey 6 years after the first one, to assess progress in HIV diagnosis and care and differences in the HIV prevalence and incidence between the two surveys. METHODS: A cross‐sectional, population‐based survey using cluster sampling and geospatial random selection was implemented in 2018, using the same design as 2012. Consenting participants aged 15–59 years were interviewed and tested for HIV at home. HIV‐positive individuals received viral load testing (viral suppression defined as <1000 copies/ml) and Lag‐Avidity EIA assay (to measure recent infection). The 90–90–90 UNAIDS indicators were also assessed. RESULTS: Overall, 6029 individuals were included in 2018. HIV prevalence was 16.9%. Viral suppression among all HIV‐positive was 88.3% in 2018 (vs. 39.9% in 2012, p < 0.001). HIV incidence was 0.75% in 2018 vs. 1.90% in 2012 (p = 0.07). In 2018, the 90–90–90 indicators were 93%–97%–95% (vs. 60%–68%–83% in 2012). CONCLUSION: A two‐fold increase in the HIV viral load suppression rate along with a decreasing trend in incidence was observed over 6 years in Ndhiwa sub‐county. Achieving high rates of viral suppression in HIV populations that can lead to reducing HIV transmission in sub‐Saharan contexts is feasible. Nevertheless, we will need further efforts to sustain this progress. John Wiley and Sons Inc. 2021-10-28 2021-12 /pmc/articles/PMC9298256/ /pubmed/34637172 http://dx.doi.org/10.1111/tmi.13688 Text en © 2021 Epicentre. Tropical Medicine & International Health published by John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Conan, Nolwenn
Badawi, Mahmoud
Chihana, Menard L.
Wanjala, Stephen
Kingwara, Leonard
Mambula, Christopher
Ngugi, Catherine
Okomo, Gordon
Opollo, Valarie
Salumu, Leon
Nesbitt, Robin
Szumilin, Elisabeth
Huerga, Helena
Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya
title Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya
title_full Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya
title_fullStr Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya
title_full_unstemmed Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya
title_short Two‐fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub‐county, Kenya
title_sort two‐fold increase in the hiv viral load suppression rate along with decreased incidence over six years in ndhiwa sub‐county, kenya
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298256/
https://www.ncbi.nlm.nih.gov/pubmed/34637172
http://dx.doi.org/10.1111/tmi.13688
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