Targeted SERPIN (TaSER): A dual‐action antithrombotic agent that targets platelets for SERPIN delivery

BACKGROUND: Occlusive thrombi are not homogeneous in composition. The core of a thrombus is rich in activated platelets and fibrin while the outer shell contains resting platelets. This core is inaccessible to plasma proteins. We produced a fusion protein (targeted SERPIN–TaSER), consisting of a fun...

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Detalles Bibliográficos
Autores principales: Sanrattana, Wariya, Smits, Simone, Barendrecht, Arjan D., van Kleef, Nadine D., El Otmani, Hinde, Zivkovic, Minka, Roest, Mark, Renné, Thomas, Clark, Chantal C., de Maat, Steven, Maas, Coen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
THROMBOSIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298318/
https://www.ncbi.nlm.nih.gov/pubmed/34653316
http://dx.doi.org/10.1111/jth.15554

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