A Bivalent Supramolecular GCP Ligand Enables Blocking of the Taspase1/Importin α Interaction

Taspase1 is a unique protease not only pivotal for embryonic development but also implicated in leukemia as well as solid tumors. As such, it is a promising target in cancer therapy, although only a limited number of Taspase1 inhibitors lacking general applicability are currently available. Here we...

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Detalles Bibliográficos
Autores principales: Höing, Alexander, Zimmermann, Alexander, Moews, Lisa, Killa, Matthias, Heimann, Marius, Hensel, Astrid, Voskuhl, Jens, Knauer, Shirley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298320/
https://www.ncbi.nlm.nih.gov/pubmed/34623765
http://dx.doi.org/10.1002/cmdc.202100640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298320/
https://www.ncbi.nlm.nih.gov/pubmed/34623765
http://dx.doi.org/10.1002/cmdc.202100640

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