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No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients

We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine‐3‐glucuronide (M3G) and morphine‐6‐glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90 min after a bolus of morphine (...

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Detalles Bibliográficos
Autores principales:	Kuhlmann, Ida, Hjelmar Petersen, Rasmus, Overgaard, Morten, Dornonville de la Cour, Kenn, Zwisler, Stine, Bjerregaard Stage, Tore, Hougaard Christensen, Mette Marie, Bergmann, Troels K., Damkier, Per, Gadegaard Jensen, Anders, Nielsen, Flemming, Brøsen, Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Clinical Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298338/ https://www.ncbi.nlm.nih.gov/pubmed/34599645 http://dx.doi.org/10.1111/bcpt.13667

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