Cargando…

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients

We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine‐3‐glucuronide (M3G) and morphine‐6‐glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90 min after a bolus of morphine (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuhlmann, Ida, Hjelmar Petersen, Rasmus, Overgaard, Morten, Dornonville de la Cour, Kenn, Zwisler, Stine, Bjerregaard Stage, Tore, Hougaard Christensen, Mette Marie, Bergmann, Troels K., Damkier, Per, Gadegaard Jensen, Anders, Nielsen, Flemming, Brøsen, Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Clinical Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298338/ https://www.ncbi.nlm.nih.gov/pubmed/34599645 http://dx.doi.org/10.1111/bcpt.13667

Ejemplares similares

Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study
por: Kuhlmann, Ida, et al.
Publicado: (2021)

Quantification of In Vivo Metabolic Activity of CYP2D6 Genotypes and Alleles Through Population Pharmacokinetic Analysis of Vortioxetine
por: Frederiksen, Trine, et al.
Publicado: (2020)

Cytochrome P450 2D6 genotype–phenotype characterization through population pharmacokinetic modeling of tedatioxetine
por: Frederiksen, Trine, et al.
Publicado: (2021)

Does ethnicity impact CYP2D6 genotype–phenotype relationships?
por: Frederiksen, Trine, et al.
Publicado: (2023)

Estimating the In Vivo Function of CYP2D6 Alleles through Population Pharmacokinetic Modeling of Brexpiprazole
por: Frederiksen, Trine, et al.
Publicado: (2022)

Pharmacokinetics of metformin in patients with gastrointestinal intolerance
por: McCreight, Laura J., et al.
Publicado: (2018)

Bridging the Translational Gap in Chemotherapy-Induced Peripheral Neuropathy with iPSC-Based Modeling
por: Mortensen, Christina, et al.
Publicado: (2022)

Sex, racial, and ethnic diversity in clinical trials
por: Bøttern, Julie, et al.
Publicado: (2023)

Tutorial: Statistical analysis and reporting of clinical pharmacokinetic studies
por: Dunvald, Ann‐Cathrine Dalgård, et al.
Publicado: (2022)

The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients
por: Madsen, Mads Juul, et al.
Publicado: (2017)

Cytochrome P450 activity in rheumatoid arthritis patients during continuous IL-6 receptor antagonist therapy
por: Dunvald, Ann-Cathrine Dalgård, et al.
Publicado: (2023)

Influence of Referral Pathway on Ebola Virus Disease Case-Fatality Rate and Effect of Survival Selection Bias
por: Rudolf, Frauke, et al.
Publicado: (2017)

Evaluation of Response Processes to the Danish Version of the Dutch Multifactor Fatigue Scale in Stroke Using the Three-Step Test-Interview
por: Dornonville de la Cour, Frederik L., et al.
Publicado: (2021)

Defining a Treatment Model for Self-Management of Fatigue in Rehabilitation of Acquired Brain Injury Using the Rehabilitation Treatment Specification System
por: Dornonville de la Cour, Frederik Lehman, et al.
Publicado: (2023)

The political practice of environmental organizations
por: Hjelmar, Ulf
Publicado: (1996)

Positive serum specific IgE has a short half-life in patients with penicillin allergy and reversal does not always indicate tolerance
por: Hjortlund, Janni, et al.
Publicado: (2014)

SearCh for humourIstic and Extravagant acroNyms and Thoroughly Inappropriate names For Important Clinical trials (SCIENTIFIC): qualitative and quantitative systematic study
por: Pottegård, Anton, et al.
Publicado: (2014)

Four phase 1 trials to evaluate the safety and pharmacokinetic profile of single and repeated dosing of SCO‐101 in adult male and female volunteers
por: Bergmann, Troels K., et al.
Publicado: (2020)

Changes in severity of traffic related trauma aged 18+ admitted to a local level 2 trauma centre after the introduction of the Mobile Emergency Care Unit at Southern Funen. A pilot study
por: Hebsgaard, Stine, et al.
Publicado: (2015)

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter
por: Emoto, C, et al.
Publicado: (2016)

In Vivo Labeling and Tracking of Proliferating Corneal Endothelial Cells by 5-Ethynyl-2′-Deoxyuridine in Rabbits
por: Correll, Mette Hedegaard, et al.
Publicado: (2021)

A Brief Overview of the Cerebrospinal Fluid System and Its Implications for Brain and Spinal Cord Diseases
por: Wichmann, Thea Overgaard, et al.
Publicado: (2022)

Vocational Rehabilitation in Mild Traumatic Brain Injury: Supporting Return to Work and Daily Life Functioning
por: Dornonville de la Cour, Frederik Lehman, et al.
Publicado: (2019)

Physician-led in-hospital multidisciplinary team conferences with multiple medical specialities present - A scoping review
por: Henriksen, Daniel Pilsgaard, et al.
Publicado: (2022)

The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer
por: Hjorth, Cathrine F., et al.
Publicado: (2023)

Depression in COPD – management and quality of life considerations
por: Stage, Kurt B, et al.
Publicado: (2006)

Motivation to take part in integrated care—an assessment of follow-up home visits to elderly persons
por: Hjelmar, Ulf, et al.
Publicado: (2011)

Single-nucleotide polymorphisms and the effectiveness of taxane-based chemotherapy in premenopausal breast cancer: a population-based cohort study in Denmark
por: Hjorth, Cathrine F., et al.
Publicado: (2022)

Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study
por: Bodilsen, Jacob, et al.
Publicado: (2021)

Investigating the Effectiveness of a Family Intervention after Acquired Brain or Spinal Cord Injury: A Randomized Controlled Trial
por: Soendergaard, Pernille Langer, et al.
Publicado: (2023)

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB
por: Overgaard, Martin, et al.
Publicado: (2009)

Morphin
por: Lenart, Kate
Publicado: (2017)

On Morphinism
Publicado: (1880)

Morphinism
por: Stockard, C. C.
Publicado: (1900)

Morphine? No! No! No!
por: Wolff, M. A. A.
Publicado: (1890)

Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide
por: de Hoogd, Sjoerd, et al.
Publicado: (2017)

Risk of recurrence and bleeding in patients with cancer‐associated venous thromboembolism treated with rivaroxaban: A nationwide cohort study
por: Søgaard, Mette, et al.
Publicado: (2019)

Measurement Properties of the Dutch Multifactor Fatigue Scale in Early and Late Rehabilitation of Acquired Brain Injury in Denmark
por: Dornonville de la Cour, Frederik Lehman, et al.
Publicado: (2023)

Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients
por: Franken, Linda G., et al.
Publicado: (2015)

Paediatric medical emergency calls to a Danish Emergency Medical Dispatch Centre: a retrospective, observational study
por: Andersen, Kasper, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hf9b6i7ldc0ioqtbpibh5m7aoa