Pseudoperoxidase activity, conformational stability, and aggregation propensity of the His98Tyr myoglobin variant: implications for the onset of myoglobinopathy

The autosomal dominant striated muscle disease myoglobinopathy is due to the single point mutation His98Tyr in human myoglobin (MB), the heme protein responsible for binding, storage, and controlled release of O(2) in striated muscle. In order to understand the molecular basis of this disease, a com...

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Detalles Bibliográficos
Autores principales: Hofbauer, Stefan, Pignataro, Marcello, Borsari, Marco, Bortolotti, Carlo Augusto, Di Rocco, Giulia, Ravenscroft, Gianina, Furtmüller, Paul G., Obinger, Christian, Sola, Marco, Battistuzzi, Gianantonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298411/
https://www.ncbi.nlm.nih.gov/pubmed/34679218
http://dx.doi.org/10.1111/febs.16235

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