Cargando…

Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up

The aim of this study was to monitor long‐term changes in bone mineral density (BMD) after menopause and factors affecting BMD. The study population consisted of a random sample of 3222 women from the Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study, of which 62.1% were postmenopausal a...

Descripción completa

Detalles Bibliográficos
Autores principales: Moilanen, Anna, Kopra, Juho, Kröger, Heikki, Sund, Reijo, Rikkonen, Toni, Sirola, Joonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298425/
https://www.ncbi.nlm.nih.gov/pubmed/34668233
http://dx.doi.org/10.1002/jbmr.4444
_version_ 1784750706216927232
author Moilanen, Anna
Kopra, Juho
Kröger, Heikki
Sund, Reijo
Rikkonen, Toni
Sirola, Joonas
author_facet Moilanen, Anna
Kopra, Juho
Kröger, Heikki
Sund, Reijo
Rikkonen, Toni
Sirola, Joonas
author_sort Moilanen, Anna
collection PubMed
description The aim of this study was to monitor long‐term changes in bone mineral density (BMD) after menopause and factors affecting BMD. The study population consisted of a random sample of 3222 women from the Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study, of which 62.1% were postmenopausal at the beginning of the study. This group of women underwent dual‐energy X‐ray absorptiometry (DXA) measurements at the femoral neck every 5 years from baseline (in 1989) up to 25‐year follow‐up. They also responded to risk‐factor questionnaires at 5‐year intervals. During the 25‐year follow‐up, the baseline cohort decreased to 686 women. The women were divided into quartiles based on their baseline BMD. Self‐reported hormone replacement therapy (HRT) and corticosteroid use were divided into ever users and never users. Morbidity was assessed as the total number of self‐reported diseases and BMD‐affecting diseases. The mean 25‐year BMD change was found to be −10.1%, p < 0.001. Higher baseline BMD was associated with higher bone loss rate; the reduction in the highest quartile BMD was 11.1% and in the lowest quartile 7.4% (p = 0.0031). Lower baseline body mass index (BMI) and a greater increase in BMI were found to protect against postmenopausal bone loss (p < 0.001). The lowest bone loss quartile included 15.2% more HRT users than the highest bone loss quartile (p = 0.004). The number of diseases/bone‐affecting diseases, use of vitamin D/calcium supplementation, use of corticosteroids, smoking or alcohol use had no statistical significance for annual bone loss rate. This study presents hitherto the longest (25‐year) BMD follow‐up in postmenopausal women. The linear femoral neck bone loss of 10% was less than previously assumed. A 5‐year BMD change appeared to predict long‐term bone loss in postmenopausal women. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
format Online
Article
Text
id pubmed-9298425
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-92984252022-07-21 Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up Moilanen, Anna Kopra, Juho Kröger, Heikki Sund, Reijo Rikkonen, Toni Sirola, Joonas J Bone Miner Res Original Articles The aim of this study was to monitor long‐term changes in bone mineral density (BMD) after menopause and factors affecting BMD. The study population consisted of a random sample of 3222 women from the Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study, of which 62.1% were postmenopausal at the beginning of the study. This group of women underwent dual‐energy X‐ray absorptiometry (DXA) measurements at the femoral neck every 5 years from baseline (in 1989) up to 25‐year follow‐up. They also responded to risk‐factor questionnaires at 5‐year intervals. During the 25‐year follow‐up, the baseline cohort decreased to 686 women. The women were divided into quartiles based on their baseline BMD. Self‐reported hormone replacement therapy (HRT) and corticosteroid use were divided into ever users and never users. Morbidity was assessed as the total number of self‐reported diseases and BMD‐affecting diseases. The mean 25‐year BMD change was found to be −10.1%, p < 0.001. Higher baseline BMD was associated with higher bone loss rate; the reduction in the highest quartile BMD was 11.1% and in the lowest quartile 7.4% (p = 0.0031). Lower baseline body mass index (BMI) and a greater increase in BMI were found to protect against postmenopausal bone loss (p < 0.001). The lowest bone loss quartile included 15.2% more HRT users than the highest bone loss quartile (p = 0.004). The number of diseases/bone‐affecting diseases, use of vitamin D/calcium supplementation, use of corticosteroids, smoking or alcohol use had no statistical significance for annual bone loss rate. This study presents hitherto the longest (25‐year) BMD follow‐up in postmenopausal women. The linear femoral neck bone loss of 10% was less than previously assumed. A 5‐year BMD change appeared to predict long‐term bone loss in postmenopausal women. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). John Wiley & Sons, Inc. 2021-10-19 2022-02 /pmc/articles/PMC9298425/ /pubmed/34668233 http://dx.doi.org/10.1002/jbmr.4444 Text en © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Moilanen, Anna
Kopra, Juho
Kröger, Heikki
Sund, Reijo
Rikkonen, Toni
Sirola, Joonas
Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up
title Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up
title_full Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up
title_fullStr Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up
title_full_unstemmed Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up
title_short Characteristics of Long‐Term Femoral Neck Bone Loss in Postmenopausal Women: A 25‐Year Follow‐Up
title_sort characteristics of long‐term femoral neck bone loss in postmenopausal women: a 25‐year follow‐up
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298425/
https://www.ncbi.nlm.nih.gov/pubmed/34668233
http://dx.doi.org/10.1002/jbmr.4444
work_keys_str_mv AT moilanenanna characteristicsoflongtermfemoralneckbonelossinpostmenopausalwomena25yearfollowup
AT koprajuho characteristicsoflongtermfemoralneckbonelossinpostmenopausalwomena25yearfollowup
AT krogerheikki characteristicsoflongtermfemoralneckbonelossinpostmenopausalwomena25yearfollowup
AT sundreijo characteristicsoflongtermfemoralneckbonelossinpostmenopausalwomena25yearfollowup
AT rikkonentoni characteristicsoflongtermfemoralneckbonelossinpostmenopausalwomena25yearfollowup
AT sirolajoonas characteristicsoflongtermfemoralneckbonelossinpostmenopausalwomena25yearfollowup